Angiogenesis y Endometriosis
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Abstract
La endometriosis se produce por un proceso de implantación y crecimiento de las células endometriales sobre la superficie peritoneal y ovárica. Al igual que los procesos tumorales los implantes de células endometriales no son capaces de proliferar a menos que exista un proceso de neoangiogénesis. Se ha propuesto que la angiogénesis endometrial excesiva pudiera ser un importante mecanismo en la patogénesis de la endometriosis. El proceso de angiogénesis implica la interacción de un elevado número de factores de crecimiento entre los que se encuentra el factor de crecimiento vascular (VEGF), el cual es reconocido como el principal factor angiogénico. En un reciente investigación hemos estudiado el papel del VEGF sérico en pacientes con endometriosis ovárica dividas en dos grupos en funcion de si presentaban o no síntomas de dolor pélvico crónico y/o dismenorrea.
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