Heritability and candidate genes for endometriosis

Joe Leigh Simpson, Bischoff F, Farideh Bischoff, Farideh Z. Bischoff
Reproductive BioMedicine Online · 2003 · vol. 7(2) , pp. 162–169 · doi:10.1016/s1472-6483(10)61746-4 · PMID:14567883 · W2057116331
Review OA: bronze CC0 ⤵ 24 in-corpus citations
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This study investigated the heritability of endometriosis and identified candidate genes associated with the condition.

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Abstract

Endometriosis is inherited in polygenic/multifactorial fashion, with recurrence risks of 5-7% for first-degree relatives. The current task is to determine the number and location of causative genes. This review initially supports the basis for polygenic/multifactorial inheritance and then outlines genome-wide strategies for identifying causative genes. Potential candidate genes are surveyed, and discrepant results emphasized. Finally, a hypothesis for endometriosis, having a multi-step pathogenesis analogous to the pathogenesis of neoplasia, is considered.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Genetic Predisposition to Disease Endometriosis Endometriosis Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (74)

Cited by (23)

Source provenance

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