Serum anti-endometrial antibodies in infertile women - potential risk factor for implantation failure

Sarapik A, Aili Sarapik, Haller-Kikkatalo K, Kadri Haller-Kikkatalo, Kadri Haller‐Kikkatalo, Utt M, Meeme Utt, Kaupo Teesalu, Teesalu K, Andres Salumets, Raivo Uibo
American journal of reproductive immunology (New York, N.Y. : 1989) · 2010 · vol. 63(5) , pp. 349–357 · doi:10.1111/j.1600-0897.2010.00808.x · PMID:20132165 · W1870983127
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This study found that IgA and IgG anti-endometrial antibodies, particularly IgA against a 47-kDa protein identified as α-enolase, were more prevalent in infertile women and associated with IVF implantation failure.

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Abstract

PROBLEM: Female infertility patients with diverse etiologies show increased production of autoantibodies. METHOD OF STUDY: Immunoblot analysis of sera from patients with endometriosis and tubal factor infertility (TFI) and mass spectrometry identification of candidate antigens. RESULTS: The immunoblot results demonstrated the presence of IgA and IgG anti-endometrial antibodies (AEA) to various antigens at molecular weights ranging from 10 to 200 kDa. Differences were detected in certain AEA reactions between the patients' groups and particular AEA were associated with in vitro fertilization (IVF) implantation failure. IgA AEA to a 47-kDa protein were more prevalent in TFI patients and were associated with unsuccessful IVF treatment. This antigen was subsequently identified as alpha-enolase. CONCLUSION: Determination of the presence and spectra of AEA in patients with endometriosis and TFI undergoing IVF may be a useful marker to predict their pregnancy outcome.

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Condition tags

endometriosisinfertility

MeSH descriptors

Autoantibodies Embryo Implantation Embryo Implantation Endometrium Immunoglobulin A Immunoglobulin G Infertility, Female Adult Adult Autoantibodies Autoantibodies Autoantibodies Biomarkers Biomarkers Biomarkers Endometriosis Endometriosis Endometriosis Endometriosis Endometrium

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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