Analysis of the serum reproductive system related autoantibodies of infertility patients in Tianjin region of China.

Yan Huo, Yanying Xu, Jianmei Wang, Fang Wang, Yu Liu, Yujuan Zhang, Bumei Zhang
In: International journal of clinical and experimental medicine · 2015 · vol. 8(8) , pp. 14048–53 · PMID:26550366 · W2206137390
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This study analyzed reproductive system autoantibodies in 3016 infertility patients and 627 controls, finding elevated levels of antisperm, anti-endometrium, anti-ovary, anticardiolipin, and anti-zona pellucida antibodies in primary infertility cases compared to controls.

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Abstract

OBJECT: Reproductive system related autoantibodies have been proposed to be associated with natural infertility. However, large scale systematic analysis of these of antibodies has not been conducted. The aim of this study is to analyze the positive rate of antisperm antibody (ASAb), anti-endometrium antibody (EMAb), anti-ovary antibody (AOAb), anti-zona pellucida antibody (AZP) and anticardiolipin antibody (ACA) in infertility patients in Tianjin region of China. METHODS: 1305 male and 1711 female primary infertility patients and 1100 female secondary infertility patients were included in this study, as well as 627 healthy female controls. The above autoantibodies were tested and the positive rates in each group were calculated. RESULTS: the positive rate of ASAb were significantly higher in primary infertility female than that in male, further analysis revealed that primary infertility population all exhibit significant higher positive rate of EMAb, AOAb, AZP and ACA compared with control group. Furthermore, the positive rates of all the antibodies in primary infertility female were significantly higher than those in secondary infertility female. CONCLUSIONS: Our study thus indicates that these autoantibodies might be associated with immunological related primary infertility and may have clinical significance in its diagnosis and treatment.

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infertility

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