Glutathione S-transferases M1/T1 gene polymorphisms and endometriosis: a meta-analysis of genetic association studies

Guo SW, Sun-Wei Guo, Sun‐Wei Guo
Molecular human reproduction · 2005 · vol. 11(10) , pp. 729–743 · doi:10.1093/molehr/gah206 · PMID:16291859 · W2108985731
Systematic review / meta-analysis OA: bronze CC0 ⤵ 48 in-corpus citations
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This meta-analysis of 14 GSTM1 studies and nine GSTT1 studies found no increased endometriosis risk with the GSTM1 null genotype but a potential 29% higher risk with the GSTT1 null genotype, though publication bias was noted.

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Abstract

In view of the controversies surrounding the glutathione S-transferases (GST) M1/T1-endometriosis association, a meta-analysis of the GSTM1/GSTT1 genetic association studies of endometriosis was performed. In this meta-analysis involving 14 GSTM1 studies with 1539 cases and 1805 controls and nine GSTT1 studies with 746 cases and 834 controls, respectively, substantial heterogeneities among studies were found. In addition, asymmetry in funnel plot was evident, which is likely to stem from publication bias, given no apparent indication of true heterogeneity. The bias appears to be prominent for GSTM1 studies, but is less so for GSTT1 studies. After correction for this bias, there is no evidence that women with GSTM1 null genotype have increased risk of developing endometriosis as compared with women with other genotypes. For GSTT1, the risk associated with the null genotype is 29% higher than other genotypes. However, even this estimate should be viewed with a large grain of salt, because the estimate could easily lose its statistical significance if there is a realistic 69-80% publication probability.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Glutathione Transferase Publication Bias Publication Bias Adult Adult Endometriosis Endometriosis Endometriosis Female Female Genotype Genotype Glutathione Transferase Glutathione Transferase Humans Humans Middle Aged Middle Aged Polymorphism, Genetic

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (48)

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