The vascular endothelial growth factor þ405G.C polymorphism in endometriosis

Davide Gentilini, Edgardo Somigliana, Paola Viganò, M. Vignali, Mauro Busacca, Anna Maria Di Blasio, Anna Maria, Di Blasio
In: http://humrep.oxfordjournals.org/content/23/1/211.full.pdf · 2015 · W2184898253
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This study investigated the VEGF +405G>C polymorphism in Italian women and found a significant association with endometriosis risk, though heterogeneity among studies suggests population-specific effects.

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Abstract

BACKGROUND: Vascular endothelial growth factor (VEGF) is a potent stimulus of angiogenesis potentially contri-buting to the pathogenesis of endometriosis. The aim of this study was to investigate the potential association between the single nucleotide polymorphism 1405G>C of the VEGF gene with the risk of endometriosis, for the first time in the Caucasian population. METHODS: The polymorphism 1405G>C of the VEGF gene was examined in n5 203 Italian women affected by endometriosis and in n 5 140 women without laparoscopic evidence of the disease. All the women were genotyped by PCR-restriction fragment length polymorphism from venous blood samples. We then performed a meta-analysis including results from the present study and from the two previously published studies on this topic. RESULTS: The distribution of the three different genotypes significantly differed between women with and without the disease (P5 0.03). The odds ratio (95 % confidence interval) for endometriosis in women carrying the C allele was 1.8 (1.2–2.8). The Breslow–Day test revealed statistically significant heterogeneity among the studies performed so far thus indicating inconsistency among studies and excluding the possibility of obtaining a common estimation of the effect. CONCLUSIONS: Results obtained herein are in keeping with those obtained previously and support a role for the 1405G>C VEGF polymorphism in endometriosis development, although a further, larger study is required to confirm our findings. However, this effect may depend on the population studied. Ethnicity and the characteristics of endometriosis are likely to influence this association.

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endometriosis

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