Endometriosis, 1995--confusion or sense?

Eileen Thomas, E J Thomas, Thomas EJ
International Journal of Gynecology & Obstetrics · 1995 · vol. 48(2) , pp. 149–155 · doi:10.1016/0020-7292(94)02277-6 · PMID:7789588 · W2001322255
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This review explores endometriosis etiology, pathogenesis, infertility links, and medical/surgical treatments, finding it common, likely caused by menstrual implantation, and best managed with individualized therapy.

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Abstract

OBJECTIVE: To review current understanding of endometriosis. METHOD: A review of etiology, pathogenesis, relationship with infertility, medical and surgical treatment. RESULTS: It is likely that endometriosis occurs in most women at some stage in their reproductive years. Exposure to menstruation and estrogen are important etiologically. Current evidence suggests that implantation of menstrual endometrium is the commonest mechanism of pathogenesis. Clinical symptoms and signs are important in the diagnosis while laparoscopy remains the prime diagnostic technique. Treatment is not indicated for infertility but is for symptoms. Danazol and progestogens represent the best first-line therapy although gonadotropin-releasing hormone agonists are appropriate if economically justifiable. Both open and laparoscopic surgery are important especially in reconstructive work. The value of laser ablation in the treatment of infertility is unknown but it is effective in pain. The disease should be regarded as a recurrent problem and treatment strategies designed appropriately. CONCLUSION: Endometriosis still represents an intellectual and therapeutic challenge but successful treatment is possible especially if it is individualized for each patient.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Adult Adult Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Biomarkers Biomarkers Biomarkers CA-125 Antigen CA-125 Antigen CA-125 Antigen Danazol

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (43)

Cited by (37)

Source provenance

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License: CC0 · commercial use OK