Endometriosis and unexplained recurrent spontaneous abortion: pathological states resulting from aberrant modulation of natural killer cell function?

Edgardo Somigliana, E Somigliana, Paola Viganò, P Viganò, M. Vignali, Vignali M
Human Reproduction Update · 1999 · vol. 5(1) , pp. 40–51 · doi:10.1093/humupd/5.1.40 · PMID:10333368 · W2125102411
Review OA: bronze CC0 ⤵ 35 in-corpus citations
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This review explores how altered natural killer cell function, found to be low in endometriosis and high in unexplained recurrent spontaneous abortion, may link these two conditions.

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Abstract

The observation that natural killer (NK) cell activity is abnormally low in endometriosis patients and abnormally high in women with otherwise unexplained recurrent spontaneous abortion represents, at present, an intriguing curiosity. There is evidence suggesting that these conditions are associated with an opposite regulation of NK cell behaviour. This review discusses these observations and potential relationships.

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Condition tags

endometriosis

MeSH descriptors

Abortion, Habitual Endometriosis Killer Cells, Natural Abortion, Habitual Abortion, Habitual Endometriosis Endometriosis Female Female Histocompatibility Antigens Class I Histocompatibility Antigens Class I Histocompatibility Antigens Class I HLA Antigens HLA Antigens HLA Antigens HLA-G Antigens HLA-G Antigens Humans Humans Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (35)

Source provenance

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License: CC0 · commercial use OK