The Concept of Endometriosis as Chronic Disease: Surgical and Medical Therapy with Hormonal and Nonhormonal Targets and the Influence of Endometriosis on Obstetrical Outcome

Liselotte Mettler, Wael Sammur, İbrahim Alkatout
In: ISGE Series · 2014 · pp. 29–47 · doi:10.1007/978-3-319-03494-2_5 · W185197511
book-chapter OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Combined surgical and hormonal therapy yielded the lowest recurrence rates for endometriosis, with improved pregnancy rates observed in medically treated patients.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This randomized clinical study evaluated three therapy strategies for genital endometriosis—hormonal medication, surgical treatment, or a combined approach—in 450 women (18–44) assessed at first laparoscopy and re-evaluated at a second-look laparoscopy after defined intervals, with outcomes focusing on symptom recurrence/cure and pregnancy rate. Overall cure rates were at least 50% across groups, with the combined surgical plus hormonal treatment achieving the highest cure rate (~60%), and pregnancy rates (about 55–65%) showing no significant differences by treatment option. The study explicitly notes that classifications such as EEC have limited predictive value, and pregnancy outcomes include multiple complications. This paper is centrally about endometriosis — it directly compares combined versus single-modality therapy for genital endometriosis and reports obstetrical outcomes and related risks.

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endometriosis

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