[Treatment of endometriosis with the GnRH analog triptorelin with special reference to the effect on bone density].
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Triptorelin treatment for endometriosis in 27 patients improved subjective symptoms and laparoscopic scoring without significant bone density loss or intolerable side effects.
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Abstract
27 patients of the department of gynecology and obstetrics of the university of Essen received a six month therapy with the GnRH-analogon triptorelin because of endometriosis diagnosed by laparoscopy. All the patients experienced not only a significant improvement in their subjective symptoms but also in their rAFS-score which was used to classify the severity of the endometriosis of our patients. We could also show that no patient experienced any severe side effects under the therapy and those side effects such as hot flushes or sweating, which appeared, were almost tolerated very well by the patients. None of the patients did leave the study because of the side effects. We were also able to demonstrate that under the therapy there was no significant loss of the bone density. The introduction of the GnRH-analogon triptorelin is therefore a major step forward in the effective therapy of patients suffering from endometriosis.
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Cited by (6)
- Human Reproduction: From State of the Art to Future Developments “Endometriosis Therapeutic Approaches” 2018
- Interdisziplinäre Diagnostik und Therapie der tief infiltrierenden Endometriose 2015
- Impact of Medical and Surgical Treatment of Endometriosis on the Cure of Endometriosis and Pain 2014
- The Concept of Endometriosis as Chronic Disease: Surgical and Medical Therapy with Hormonal and Nonhormonal Targets and the Influence of Endometriosis on Obstetrical Outcome 2014
- Medikamentöse und operative Therapieoptionen 2013
- Long-term follow-up on the treatment of endometriosis with the GnRH-agonist buserelinacetate Long-term follow-up data (up to 98 months) of 42 patients with endometriosis who were treated with GnRH-agonist buserelinacetate (Suprecur®), were evaluated in respect of recurrence of pain symptoms and pregnancy outcome 1997
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