Combined Surgical and Hormone Therapy for Endometriosis is the Most Effective Treatment: Prospective, Randomized, Controlled Trial

Ibrahim Alkatout; Liselotte Mettler; Carmen Beteta; Jürgen Hedderich; W. Jonat; Walter Jonat; Thoralf Schollmeyer; Ali Salmassi

doi:10.1016/j.jmig.2013.01.019

Combined Surgical and Hormone Therapy for Endometriosis is the Most Effective Treatment: Prospective, Randomized, Controlled Trial

Ibrahim Alkatout, Liselotte Mettler, Carmen Beteta, Jürgen Hedderich, W. Jonat, Walter Jonat, Thoralf Schollmeyer, Ali Salmassi

Journal of minimally invasive gynecology · 2013 · vol. 20(4) , pp. 473–481 · doi:10.1016/j.jmig.2013.01.019 · PMID:23567095 · W1971470712

article OA: closed CC0 ⤵ 86 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This trial demonstrates that combining surgical intervention with hormone therapy offers the most effective treatment strategy for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertility Agents, Female Genital Diseases, Female Laparoscopy Leuprolide Adolescent Adult Combined Modality Therapy Endometriosis Endometriosis Endometriosis Female Fertility Agents, Female Genital Diseases, Female Genital Diseases, Female Genital Diseases, Female Humans Leuprolide Prospective Studies Treatment Outcome

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References (36)

Add-back therapy in the treatment of endometriosis-associated pain via openalex
Behandlung von Endometriose mit dem GnRH-Agonisten Buserelin (Suprecur®): Eine multizentrische Studie via openalex
Deep endometriosis: definition, diagnosis, and treatment via openalex
Diagnostik und Therapie der Endometriose via openalex
Diagnostik und Therapie der Endometriose via openalex
Differences in characteristics among 1,000 women with endometriosis based on extent of disease via openalex
Endometriosis via openalex
Endometriosis via openalex
ESHRE guideline for the diagnosis and treatment of endometriosis via openalex
Laparoscopic excision of endometriosis: A randomized, placebo-controlled trial via openalex
Laparoscopic Management of Endometriosis: Comprehensive Review of Best Evidence via openalex
Laparoscopic surgery for pelvic pain associated with endometriosis via openalex
Laparoscopic surgery for pelvic pain associated with endometriosis via openalex
Laparoscopic Surgery in Infertile Women with Minimal or Mild Endometriosis via openalex
Modern combined oral contraceptives for pain associated with endometriosis via openalex
Modern combined oral contraceptives for pain associated with endometriosis. via openalex
Ovulation suppression for endometriosis via openalex
Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis via openalex
Pre and post-operative medical therapy for endometriosis surgery via openalex
Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis via openalex
Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis via openalex
Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis via openalex
REVIEW: Accuracy of laparoscopy in the diagnosis of endometriosis: a systematic quantitative review via openalex
Surgical treatment of endometriosis: a prospective randomized double-blinded trial comparing excision and ablation via openalex
The impact of treatment on the natural history of endometriosis via openalex
Therapie der Endometriose unter Berücksichtigung der Aktivitätsgrade via openalex
Three step medical and surgical treatment of endometriosis via openalex
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Cited by (50)

Source provenance

europepmc: last seen: 2026-06-11T06:19:48.454388+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-13T22:19:05.543671+00:00

License: CC0 · commercial use OK

[1] Add-back therapy in the treatment of endometriosis-associated pain via openalex

[2] Behandlung von Endometriose mit dem GnRH-Agonisten Buserelin (Suprecur®): Eine multizentrische Studie via openalex

[3] Deep endometriosis: definition, diagnosis, and treatment via openalex

[4] Diagnostik und Therapie der Endometriose via openalex

[5] Diagnostik und Therapie der Endometriose via openalex

[6] Differences in characteristics among 1,000 women with endometriosis based on extent of disease via openalex

[7] Endometriosis via openalex

[8] Endometriosis via openalex

[9] ESHRE guideline for the diagnosis and treatment of endometriosis via openalex

[10] Laparoscopic excision of endometriosis: A randomized, placebo-controlled trial via openalex

[11] Laparoscopic Management of Endometriosis: Comprehensive Review of Best Evidence via openalex

[12] Laparoscopic surgery for pelvic pain associated with endometriosis via openalex

[13] Laparoscopic surgery for pelvic pain associated with endometriosis via openalex

[14] Laparoscopic Surgery in Infertile Women with Minimal or Mild Endometriosis via openalex

[15] Modern combined oral contraceptives for pain associated with endometriosis via openalex

[16] Modern combined oral contraceptives for pain associated with endometriosis. via openalex

[17] Ovulation suppression for endometriosis via openalex

[18] Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis via openalex

[19] Pre and post-operative medical therapy for endometriosis surgery via openalex

[20] Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis via openalex

[21] Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis via openalex

[22] Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis via openalex

[23] REVIEW: Accuracy of laparoscopy in the diagnosis of endometriosis: a systematic quantitative review via openalex

[24] Surgical treatment of endometriosis: a prospective randomized double-blinded trial comparing excision and ablation via openalex

[25] The impact of treatment on the natural history of endometriosis via openalex

[26] Therapie der Endometriose unter Berücksichtigung der Aktivitätsgrade via openalex

[27] Three step medical and surgical treatment of endometriosis via openalex

[28] W2157853773 via openalex

[29] W2133944677 via openalex

[30] W2068241143 via openalex

[31] W4285719527 via openalex

[32] W6638602116 via openalex

[33] W6678669448 via openalex

[34] W6825204538 via openalex

[35] W2500059370 via openalex

[36] W2071564400 via openalex