To excise or ablate endometriosis? A prospective randomized double-blinded trial after 5-year follow-up

Healey M, Martin Healey, Claudia Cheng, Harvinder Kaur, Kaur H
Journal of Minimally Invasive Gynecology · 2014 · vol. 21(6) , pp. 999–1004 · doi:10.1016/j.jmig.2014.04.002 · PMID:24768960 · W2093552437
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This prospective randomized double-blinded trial followed patients for five years to compare surgical excision versus ablation for treating endometriosis.

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Abstract

STUDY OBJECTIVE: To compare reduction of pain after laparoscopy for ablation or excision of endometriosis. DESIGN: Prospective, randomized, double-blind study (Canadian Task Force classification I). SETTING: Endometriosis and pelvic pain clinic at a university teaching hospital. PATIENTS: Women of reproductive age with pelvic pain and visually proved endometriosis. INTERVENTIONS: Subjects completed a questionnaire rating various kinds of pain using visual analog scales (VAS). After visual identification subjects were randomized to treatment via ablation or excision by supervised training gynecologists as primary surgeons. Follow-up questionnaires documented pain levels every 3 months for 1 year and then every 6 months for 5 years. MEASUREMENTS AND MAIN RESULTS: Change in pain VAS scores during 5 years after the operation and rates of pregnancy, repeat surgery, and use of hormone therapy were evaluated. There was a reduction in all pain scores over the 5-year follow-up in both treatment groups. A significantly greater reduction in dyspareunia VAS scores was observed in the excision group at 5 years (p = .03 at univariate analysis, and p = .007 at multivariate analysis). More women in the ablation group continued to receive medical treatment of endometriosis at 5 years (p = .004). CONCLUSIONS: Surgical treatment of endometriosis provides symptom reduction for up to 5 years. In some limited areas such as deep dyspareunia, excision is more effective than ablation.

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Condition tags

dyspareuniaendometriosischronic_pelvic_pain

MeSH descriptors

Endometrial Ablation Techniques Endometrial Ablation Techniques Endometriosis Laparoscopy Laparoscopy Pelvic Pain Adolescent Adolescent Adult Adult Canada Canada Double-Blind Method Double-Blind Method Dyspareunia Dyspareunia Dyspareunia Dyspareunia Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (50)

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