Effect of endometrioma cystectomy on IVF outcome: a prospective randomized study

Aygül Demi̇rol, Aygül Demirol, Demirol A, Suleyman Guven, Süleyman Güven, Cem Baykal, Baykal C, Timur Gürgan, Gurgan T, Timur Gurgan
Reproductive BioMedicine Online · 2006 · vol. 12(5) , pp. 639–643 · doi:10.1016/s1472-6483(10)61192-3 · PMID:16790114 · W2081808427
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This prospective randomized study investigated the impact of endometrioma cystectomy on IVF outcomes.

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Abstract

The study was conducted to investigate the effect of conservative surgery of ovarian endometriomas before an ICSI cycle. Ninety-nine patients with endometriomas who were referred to an intracytoplasmic sperm injection (ICSI) cycle were enrolled in the study. The patients were prospectively randomized into two groups; group I (49 patients) underwent conservative ovarian surgery before the ICSI cycle and group II (50 patients) underwent the ICSI cycle directly. The stimulation was started 3 months after the operation in group I and directly in group II. In the ovarian surgery group, stimulation was significantly longer (14.0 days in group I and 10.8 days in group II; P = 0.001), total recombinant FSH dose was significantly higher (4575 IU in group I and 3675 IU in group II; P = 0.001), and mean number of mature oocytes was significantly lower (7.8 in group I and 8.6 in group II; P = 0.032). There was no difference in terms of fertilization (86% in group I and 88% in group II), implantation (16.5% in group I and 18.5% in group II) and pregnancy rates (34% in group I and 38% in group II). Ovarian surgery resulted in longer stimulation, higher FSH requirement and lower oocyte number, but fertilization, pregnancy and implantation rates did not differ between the groups.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Fertilization in Vitro Gynecologic Surgical Procedures Ovarian Diseases Adult Adult Embryo Implantation Embryo Implantation Endometriosis Endometriosis Female Female Fertilization in Vitro Fertilization in Vitro Gynecologic Surgical Procedures Gynecologic Surgical Procedures Humans Humans Oocytes Oocytes

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