Recurrent implantation failure in assisted reproduction: how to counsel and manage. A. General considerations and treatment options that may benefit the couple

Urman B, Bulent Urman, Bülent Urman, Kayhan Yakın, Kayhan Yakin, Balaban B, Basak Balaban, Başak Balaban
Reproductive biomedicine online · 2005 · vol. 11(3) , pp. 371–381 · doi:10.1016/s1472-6483(10)60846-2 · PMID:16176681 · W2081413967
review OA: bronze CC0 ⤵ 8 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review discusses general considerations and treatment options to counsel and manage couples experiencing recurrent implantation failure in assisted reproduction.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Recurrent implantation failure is a distressing phenomenon, both for the infertile couple and for the physician responsible for their treatment. Aetiology is often not clear and treatment options are vague. Particularly when transferred embryos are of good quality, recurrent implantation failure may be attributed to less than optimal embryo transfer technique, pathological lesions of the uterine cavity, the presence of hydrosalpinges, fibroids and endometriosis. Poor embryo quality, especially when repetitive, is a major impediment to successful implantation and cannot be corrected at the present time. Molecular abnormalities at the endometrial level and abnormal embryo-endometrium dialogue may be responsible for some cases of recurrent implantation failure. Furthermore, there may be over- or under-expressed genes that may be related to successful implantation. At the present time, the physician confronted with a couple presenting with recurrent implantation failure should discuss openly the potential causes of this phenomenon, with special emphasis on correctable causes, and offer remedies that are evidence based.

My notes (saved in your browser only)

MeSH descriptors

Embryo Implantation Infertility, Female Infertility, Female Reproductive Techniques, Assisted Counseling Counseling Counseling Embryo Transfer Fallopian Tubes Fallopian Tubes Female Humans Infertility, Female Infertility, Female Leiomyoma Leiomyoma Male Ovulation Induction Ovulation Induction Ovulation Induction

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (8)

Source provenance

europepmc
last seen: 2026-07-28T06:14:09.330459+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:15:29.922408+00:00
License: CC0 · commercial use OK