Flushing the endometrium prior to the embryo transfer does not affect the pregnancy rate

Murat Berkkanoğlu, M Isikoglu, Murat Seleker, K Ozgur
In: Reproductive BioMedicine Online · 2006 · vol. 13(2) , pp. 268–271 · doi:10.1016/s1472-6483(10)60625-6 · PMID:16895645 · W2007159734
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⚙ AI-generated summary by claude@2026-06, 2026-06-28 ⓘ

This study investigated the impact of endometrial flushing before embryo transfer on pregnancy rates and found no significant difference between the flushing and non-flushing groups.

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Abstract

This study aimed to determine whether direct flushing of endometrial cavity with culture media just after cervical irrigation at the time of embryo transfer has any effect on pregnancy rates. A total of 240 women were prospectively randomised; one group of patients (group 1) underwent intrauterine direct flushing of endometrial cavity with culture media just after cervical irrigation at the time of embryo transfer as detected by transabdominal ultrasound and the other group of patients (group 2) had cervical flushing but did not undergo intrauterine flushing. Pregnancy (positive human chorionic gonadotrophin) rates were 57.5% and 62.9% for group 1 and group 2, respectively. Clinical pregnancy (positive fetal heart rate) rates were 45.2% and 51.4% for group 1 and group 2, respectively. Implantation rates were 20.0% and 21.2% for group 1 and group 2, respectively. Ongoing pregnancy (>12 weeks of pregnancy) rates were 47.9% and 47.2% for group 1 and group 2, respectively. There were no significant differences in pregnancy rates, clinical pregnancy rates, implantation rates and ongoing pregnancy rates between the two groups. In conclusion, even direct flushing of media into the uterine cavity neither improves nor adversely affects the pregnancy rate.

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