The oil-resin of the tropical rainforest tree Copaifera langsdorffii reduces cell viability, changes cell morphology and induces cell death in human endometriotic stromal cultures

Henriques da Silva J, Julianna Henriques da Silva, Borges VR, Vinicius Raphael de Almeida Borges, Vinícius Raphael de Almeida Borges, Pereira Lda C, Leonardo da Cunha Boldrini Pereira, Leonardo Pereira, Renato Ferrari, Ferrari R, de Mattos RM, Rômulo Medina de Mattos, Barros EG, Eliane Gouvêa de Oliveira Barros, Eliane Gouveia de Oliveira Barros, Palmero CY, Celia Yelimar Palmero, Fernandes PD, Patricia Dias Fernandes, Patrícia Dias Fernandes, de Carvalho PR, Patricia Ribeiro de Carvalho, Patrícia Ribeiro de Carvalho, Pereira de Sousa V, Valéria Pereira de Sousa, Valeria Pereira de Sousa, Cabral LM, Lucio Mendes Cabral, Lúcio Mendes Cabral, Luiz Eurico Nasciutti, Nasciutti LE
The Journal of pharmacy and pharmacology · 2015 · vol. 67(12) , pp. 1744–1755 · doi:10.1111/jphp.12479 · PMID:26407531 · W2119661012
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Copaifera langsdorffii oil-resin reduced cell viability, altered cell morphology, and induced cell death in human endometriotic stromal cells more significantly than in eutopic cells.

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Abstract

OBJECTIVES: The hormonal treatment for endometriosis frequently fails to completely eradicate endometriotic implants. A new therapeutic treatment is needed. This study investigates the in-vitro effect of Copaifera langsdorffii oil-resin on human eutopic and ectopic endometrium stromal cell cultures (EuESCs and EctESCs). METHODS: A nanocomposite system containing the copaiba oil-resin (NanoCOR) was developed and acute toxicity test was performed. Endometrial stromal cells (ESCs) from non-endometriotics controls (CESCs), EuESCs and EctESCs were isolated and treated with different concentrations of NanoCOR, at different time intervals to evaluate its effect on cell morphology, proliferation, viability, necrosis and apoptosis induction. KEY FINDINGS: When treated with 50 μg/ml of NanoCOR, the morphology of EctESCs changed, as the actin microfilaments were disorganized, disassembled or disrupted. Moreover, at 24 h of treatment with NanoCOR, the EctESCs viability was inhibited, and a significant number of these cells underwent apoptosis. In EuESCs, these effects were observed only at 48 h. Finally, the treatment of EctESCs with NanoCOR increased the lactate dehydrogenase release into the extracellular medium more than in EuESCs. CONCLUSIONS: Our data indicate that NanoCOR has a greater impact on the behaviour of human endometriotic stromal cells than on the eutopic endometrium stromal cells, supporting the idea that NanoCOR should be further investigated as a novel and valuable alternative to treat endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cell Shape Endometriosis Endometrium Fabaceae Plant Oils Resins, Plant Stromal Cells Trees Trees Actin Cytoskeleton Actin Cytoskeleton Actin Cytoskeleton Actin Cytoskeleton Animals Animals Apoptosis Apoptosis Apoptosis Case-Control Studies Case-Control Studies

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