Development and pharmacological evaluation of in vitro nanocarriers composed of lamellar silicates containing copaiba oil-resin for treatment of endometriosis

Vinícius Raphael de Almeida Borges, de Almeida Borges VR, Julianna Henriques da Silva, da Silva JH, Barbosa SS, Samantha Soares Barbosa, Luiz Eurico Nasciutti, Nasciutti LE, Cabral LM, Lúcio Mendes Cabral, Valeria Pereira de Sousa, Valéria Pereira de Sousa
Materials science & engineering. C, Materials for biological applications · 2016 · vol. 64 , pp. 310–317 · doi:10.1016/j.msec.2016.03.094 · PMID:27127058 · W2325290323
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Researchers developed and evaluated in vitro nanocarriers made of lamellar silicates loaded with copaiba oil-resin for potential use in endometriosis treatment.

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Abstract

In this work, newly developed nanocomposites based upon lamellar silicates are evaluated to determine their potential in controlling endometriosis. The preparation of the new nanocarriers is detailed, properties characterized and in vitro pharmacological evaluation performed. The nanocomposites in this study were obtained from the reaction of copaiba oil-resin (COPA) with the polymer polyvinylpyrrolidone (PVP K-30). COPA was selected due to its antiinflammatory and anticancer activities along with the organophilic derivatives of sodium montmorillonite, Viscogel B8, S7 and S4. The results indicated that it was feasible to obtain a good yield of a COPA nanocomposite using a simple process. Intercalation was confirmed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). In vitro release experiments demonstrated that COPA was released from the nanocomposite in a delayed fashion. Whereas, in vitro pharmacological studies showed a reduction in viability and proliferation of endometriotic cell cultures upon COPA nanocomposite treatment, suggesting that the system developed here can be a promising alternative therapy for the oral treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Balsams Balsams Balsams Drug Carriers Drug Carriers Drug Carriers Endometriosis Endometrium Nanocomposites Silicates Silicates Silicates Cells, Cultured Endometriosis Endometriosis Endometrium Endometrium Female Humans Nanocomposites

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