Clinical observation on patients with endometriosis treated by tonifying Kidney and removing blood stasis

This clinical observation study enrolled 103 patients with endometriosis who were randomly assigned to receive either the Neiyixiao recipe (58 cases) aimed at tonifying Kidney and removing blood stasis or danazol as a control (45 cases). After treatment, the authors assessed symptom improvement (including dysmenorrhea), infertility outcomes, endocrine hormones (FSH, LH, PRL, E2, progesterone, testosterone), immune measures (C3, C4, CD3, CD4, CD8), and plasma prostaglandins. They reported no significant between-group difference for dysmenorrhea relief or for reducing elevated plasma prostaglandin levels, but found a significantly better infertility cure rate with Neiyixiao and superior effects on endocrine and immune regulation compared with danazol. The paper’s conclusion states that the therapy is multi-effective, but it does not detail methodological limitations such as blinding or follow-up duration. This paper is centrally about endometriosis — it tests Neiyixiao recipe treatment (tonifying Kidney and removing blood stasis) in patients with endometriosis and compares outcomes with danazol.

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