Effects of Yiweining Recipe on expressions of metalloproteinase-2 and cyclooxygenase-2 mRNAs in ectopic endometrium of rats with endometriosis

Fan Qu, Jue Zhou, Dong-Xia Yang, Wen-Guang Ma, Bao-Zhang Ma
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine · 2006 · pp. 634–638 · doi:10.3736/jcim20060619 · W2055680308
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Yiweining Recipe reduced the expressions of metalloproteinase-2 and cyclooxygenase-2 mRNAs in the ectopic endometrium of rats with induced endometriosis.

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Abstract

To explore the effects of Yiweining Recipe (YWNR), a compound Chinese herbal medicine, on expressions of metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) mRNAs in rats with endometriosis (EM).Operational self-transplantation was applied in establishing the rat models. Detection of MMP-2 and COX-2 mRNAs was conducted with hybridization in situ.There were significant differences in the expressions of MMP-2 and COX-2 mRNAs between the untreated group and the high-dose YWNR-treated group. YWNR could reduce the expressions of MMP-2 and COX-2 mRNAs.YWNR can treat EM through reducing the positive expressions of MMP-2 and COX-2 mRNAs.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cyclooxygenase 2 Drugs, Chinese Herbal Endometriosis Matrix Metalloproteinase 2 Phytotherapy Uterine Diseases Animals Cyclooxygenase 2 Drugs, Chinese Herbal Drugs, Chinese Herbal Endometriosis Endometriosis Endometriosis Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Enzymologic Matrix Metalloproteinase 2 Random Allocation Rats Rats, Wistar

Citation neighborhood

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References (23)

Cited by (6)

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