Mechanisms of development of prolactin-induced adenomyosis in mice
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Ectopic pituitary transplantation induced adenomyosis in mice, characterized by stromal fibroblast and uterine gland invasion into the myometrium, suggesting mechanisms for prolactin-induced pathological uterine changes.
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Abstract
Ectopic (intrauterine and under the renal capsule) pituitary transplantation induced a high incidence of adenomyosis with subserous nodules in both SHN and SLN strains of mice. Early signs of the development were the invasion of stromal fibroblasts into the myometrium along the branches of blood vessels, followed by uterine gland invasion of the musculature to the serosa. Pituitary grafting did not modify the effects of carcinogens on the uterus. Mechanisms of the development of adenomyosis and hormonal milieu facilitating these pathological changes of the uterus are discussed.
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Cited by (46)
- Increased local prolactin synthesis in the myometrium and endometrium as a probable cause of adenomyosis 2026
- The state of hormonal balance in women with adenomyosis according to the phases of the menstrual cycle and its dependence on the stage of the disease 2025
- The effects of prolactin receptor blockade in a murine endometriosis interna model 2022
- Unveiling the Pathogenesis of Adenomyosis through Animal Models 2022
- Uterine Embolization as a New Treatment Option in Adenomyosis Uteri 2022
- Functional Implications of Estrogen and Progesterone Receptors Expression in Adenomyosis, Potential Targets for Endocrinological Therapy 2022
- Endometriosis - Recent Advances, New Perspectives and Treatments 2021
- The Interplay Between Prolactin and Reproductive System: Focus on Uterine Pathophysiology 2020
- Serum prolactin and CA 125 levels in uterine adenomyosis 2020
- β-catenin activates TGF-β-induced epithelial-mesenchymal transition in adenomyosis 2020
- Animal Models of Adenomyosis 2020
- No 164 - Directive clinique de consensus pour la prise en charge de la douleur pelvienne chronique 2018
- Effects of Ovarian Pathologies and Uterine Inflammations on Adenomyosis in Bitches 2018
- No. 164-Consensus Guidelines for the Management of Chronic Pelvic Pain 2018
- The Pathophysiology of Adenomyosis 2015
- The Animal Model of Adenomyosis 2015
- Improving the Preclinical Mouse Efficacy Studies of Adenomyosis 2015
- β-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition 2013
- The possible role of fluoxetine in adenomyosis: an animal experiment with clinical correlations 2013
- Methodological Issues in Preclinical Mouse Efficacy Studies of Adenomyosis 2012
- Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis 2011
- Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis 2011
- Neonatal administration of tamoxifen causes disruption of myometrial development but not adenomyosis in the C57/BL6J mouse 2010
- Secretion of Prolactin Following Three Dimensional Culture of Human Endometrial Tissue. 2009
- Experimental adenomyosis 2006
- Consensus guidelines for the management of chronic pelvic pain 2005
- Probucol, a hypocholesterolemic agent, prevents the development of uterine adenomyosis induced by pituitary grafting in mice 2004
- Adenomyosis 2003
- Effects of angiogenesis inhibitor TNP-470 on the development of uterine adenomyosis in mice 2003
- Molecular mechanisms contributing to the pathogenesis of endometriosis 2002
- Suppression of the development of experimentally induced uterine adenomyosis by a novel matrix metalloproteinase inhibitor, ONO-4817, in mice 2001
- Increased microvessel density in adenomyosis uteri 2001
- Changes in Uterine Microvessels as a Possible Pathogenic Factor in the Development of Adenomyosis Induced by Pituitary Grafting in Mice. 1999
- Induction of endometriosis and adenomyosis by transvaginal pituitary transplantation in mice with and without natural killer cell activity 1998
- Pathophysiology of adenomyosis 1998
- Prolactin secretion in endometriotic patients 1997
- Adenomyosis 1995
- Suppression of the development of uterine adenomyosis by danazol treatment in mice 1992
- Animal model of uterine adenomyosis: is prolactin a potent inducer of adenomyosis in mice? 1991
- Multiple Endocrine Syndrome in SHN Mice: Mammary Tumors and Uterine Adenomyosis 1989
- Adenomyosis: current perspectives 1989
- Suppression of normal and preneoplastic mammary growth and uterine adenomyosis with reduced growth hormone level in SHN mice given monosodium glutamate neonatally 1985
- Ectopic pituitary grafts in mice: hormone levels, effects on fertility, and the development of adenomyosis uteri, prolactinomas, and mammary carcinomas 1985
- Endometriosis and various pelvic lesions associated with hyperprolactinemia 1985
- Ultrastructural changes in uterine myometrium of mice with experimentally-induced adenomyosis 1984
- Endometriosis associated with hyperprolactinaemia 1984
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