Suppression of normal and preneoplastic mammary growth and uterine adenomyosis with reduced growth hormone level in SHN mice given monosodium glutamate neonatally

Nagasawa H, Hiroshi Nagasawa, H. Nagasawa, Yuuji Noguchi, Noguchi Y, Y Noguchi, Mori T, Takao Mori, T Mori, K Niki, Niki K, Kaoru Niki, Namiki H, H Namiki, Hideo Namiki
European journal of cancer & clinical oncology · 1985 · vol. 21(12) , pp. 1547–1551 · doi:10.1016/0277-5379(85)90250-0 · PMID:3830732 · W2006669151
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Neonatal monosodium glutamate administration to SHN mice suppressed normal and preneoplastic mammary growth and uterine adenomyosis by reducing growth hormone levels.

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Abstract

As a step in the evaluation of the role of growth hormone (GH) in mammary tumorigenesis, the effects of neonatal treatment with monosodium glutamate (MSG) on normal and neoplastic mammary growth, plasma levels of GH and prolactin (PRL) and the pattern of estrous cycles were determined in SHN virgin mice. The development of uterine adenomyosis, which is under similar hormonal control, was also examined in these mice. The formation of precancerous mammary hyperplastic alveolar nodules (HAN) was markedly inhibited and the number of 'ghosts', the remnants of regressed HAN, was increased by the single injection of 4 mg MSG on the day of birth, although spontaneous mammary tumorigenesis was not inhibited. The incidence of adenomyosis was suppressed by MSG treatment. Plasma GH level was chronically lower in the MSG-treated mice than in the controls. In contrast, plasma PRL levels and the pattern of estrous cycles were little affected by the treatment. These results indicate an involvement of GH in the development of HAN and uterine adenomyosis in mice.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Glutamates Growth Hormone Mammary Glands, Animal Mammary Neoplasms, Experimental Precancerous Conditions Sodium Glutamate Uterine Neoplasms Animals Animals, Newborn Body Weight Body Weight Endocrine Glands Endocrine Glands Endometriosis Estrus Estrus Female Glutamates Growth Hormone

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