Serum prolactin and CA 125 levels in uterine adenomyosis

Ayçağ Yorgancı, Nezaket Kadıoğlu, Harika Gümgümcü, Şebnem Özyer, Yaprak Engin Üstün
In: Journal of Endometriosis and Pelvic Pain Disorders · 2020 · vol. 12(3-4) , pp. 165–169 · doi:10.1177/2284026520946207 · W3047957368
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found no significant difference in serum prolactin and cancer antigen 125 levels between adenomyosis patients with smaller versus larger uterine volumes.

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Abstract

Objective: It is suggested that prolactin has a role in the pathogenesis of uterine adenomyosis. Besides, it is also reported that elevated cancer antigen 125 levels are related with this benign disorder. The aim of the study was to investigate serum prolactin and cancer antigen 125 levels in patients with adenomyosis. Methods: In this retrospective chart review study, data of patients with clinically diagnosed and histopathologically proven adenomyosis in hysterectomy specimens were analyzed. Patients were divided into two groups according to the ultrasonographically calculated preoperative uterine volume: Group 1 (n = 62): uterine volume ⩽240 cm 3 (⩽12 gestational weeks) and Group 2 (n = 42): uterine volume >240 cm 3 (>12 gestational weeks). Age, obstetric history, body mass index, preoperative hemoglobin, thyroid stimulating hormone, prolactin and cancer antigen 125 levels, and ultrasonographic findings were recorded. Preoperative prolactin and cancer antigen 125 values were compared between the two groups. Results: A total of 104 patients were included in the study. No differences in the baseline characteristics were observed between the groups, except the number of pregnancies and miscarriages. Furthermore, no significant differences were observed in terms of serum prolactin and cancer antigen 125 levels between the groups. Conclusion: Serum prolactin and cancer antigen 125 levels were not associated with uterine volume in patients with uterine adenomyosis.

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Condition tags

adenomyosis

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