Dienogest and deep infiltrating endometriosis: The remission of symptoms is not related to endometriosis nodule remission

Leonardo-Pinto JP, João Paulo Leonardo-Pinto, Joao Paulo Leonardo-Pinto, Benetti-Pinto CL, Cristina Laguna Benetti-Pinto, Cristina Laguna Benetti‐Pinto, Kleber Cursino, Cursino K, Daniela Angerame Yela, Yela DA
European journal of obstetrics, gynecology, and reproductive biology · 2017 · vol. 211 , pp. 108–111 · doi:10.1016/j.ejogrb.2017.02.015 · PMID:28231497 · W2587994610
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This study investigated the relationship between Dienogest treatment and deep infiltrating endometriosis nodules, finding symptom remission did not correlate with nodule remission.

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Abstract

OBJECTIVE: To evaluate the effectiveness of dienogest in controlling pain caused by deep infiltrating endometriosis (DIE), its influence on the quality of live (QoL) of women affected by the disease, and the effect of the drug on the volume of endometriotic lesions. STUDY DESIGN: A prospective cohort study including 30 women with a sonographic diagnosis of DIE (intestinal and posterior fornix) treated with dienogest 2mg per day for 12 months. We evaluated the pain symptoms and the volume of the intestinal and posterior fornix lesions before and after 12 months of use of dienogest. To perform the statistical analysis, we used the Wilcoxon signed-rank test, and the relationship between the data was tested using the Spearman correlation coefficient. RESULTS: Women were on average 36.13±6.24years old. Pain symptoms most commonly reported were dyspareunia (83.3%), dysmenorrhea (73.3%), and pelvic pain (66.7%). After 12 months of treatment with dienogest, there was significant improvement of various symptoms (dyspareunia p=0.0093, dysmenorrhea p<0.0001; pelvic pain p=0.0007; and bowel pain p<0.0001), without a reduction in the volume of endometriotic nodules. There were significant improvements in the parameters that comprise the QoL (physical p<0.0001; p=0.0007 psychological) and the self-assessment of QoL (p=0.0069) and health (p=0.0001). CONCLUSION: Dienogest is an effective medication to control symptoms of pain related to DIE, even without reducing the volume of DIE nodules.

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Condition tags

endometriosischronic_pelvic_paindie_deep_infiltrating

MeSH descriptors

Endometriosis Hormone Antagonists Intestinal Diseases Nandrolone Pelvic Pain Adult Adult Constipation Constipation Constipation Constipation Constipation Endometriosis Endometriosis Endometriosis Endometriosis Female Female Hormone Antagonists Hormone Antagonists

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (42)

Cited by (50)

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