Intraperitoneal and subcutaneous treatment of experimental endometriosis with recombinant human interferon-alpha-2b in a murine model

José Ma R. Ingelmo, Ingelmo JM, J M Ingelmo, F Quereda, Francisco Quereda, Pedro Acién, P Acién, Acién P
Fertility and sterility · 1999 · vol. 71(5) , pp. 907–911 · doi:10.1016/s0015-0282(99)00087-4 · PMID:10231055 · W2045757011
Other OA: closed CC0 ⤵ 69 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This study investigated the effects of intraperitoneal and subcutaneous administration of recombinant human interferon-α-2b on experimental endometriosis in mice.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To determine the effect of human interferon (IFN)-alpha-2b on experimental endometriosis in rats. DESIGN: Experimental, controlled, double-blind randomized study. SETTING: Experimental surgery laboratory in a university department. ANIMAL(S): Ninety-six Wistar rats with endometriosis, induced by transplanting four endometrial fragments into the peritoneal cavity. INTERVENTION(S): One third of the animals served as controls (group A). The others were randomly divided into two groups and were given IFN-alpha-2b either as a single intraperitoneal dose (group B) or as three SC doses (on alternate days) (group C). MAIN OUTCOME MEASURE(S): Laparotomy was performed to measure the size of each implant at various times (days 0, 6, 12, 20, and 120 after treatment). RESULT(S): There were no differences among the groups in the size of the average implants before IFN was administered (17.3+/-6.7, 19.7+/-7.8, and 18.1+/-9.2 mm for groups A, B, and C, respectively). These values were significantly smaller after treatment in group B (14.9+/-8.0 mm) and group C (14.0+/-9.5 mm) than in the control group (17.6+/-7.5 mm) (P<.05). Intraperitoneal IFN produced an initial maximum decrease in the size of the implants (40% reduction on day 6), which diminished until day 20 (20%) and then was maintained on a plateau until day 120 (25%). By contrast, group C showed an initial minimal reduction (13% at day 6), which increased up to day 20 (19%), after which a plateau was reached (23% at day 120). Thus, the effects in both treatment groups were similar in the long term. CONCLUSION(S): Two short regimens of human IFN-alpha-2b reduced the size of experimental endometriosis in rats.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Interferon-alpha Animals Animals Disease Models, Animal Disease Models, Animal Double-Blind Method Double-Blind Method Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Injections, Intraperitoneal Injections, Intraperitoneal Injections, Subcutaneous

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (24)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-17T06:09:56.316927+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T20:58:57.924351+00:00
unpaywall
last seen: 2026-08-14T06:25:32.811723+00:00
License: CC0 · commercial use OK