Advances in endometriosis research: animal models for the study of reproductive disorders

Mingjuan Zhou, Xingchen Zhou, Zhou X, Wang X, Xipeng Wang
Biology of reproduction · 2025 · vol. 113(3) , pp. 494–510 · doi:10.1093/biolre/ioaf089 · PMID:40226981 · W4409433640
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This review examines advancements in animal models, particularly nonhuman primates and rodents, for studying endometriosis-related infertility and guiding researchers in selecting appropriate models for pathogenesis and treatment investigations.

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Abstract

Endometriosis (EMS) is a significant contributor to female infertility, with its underlying mechanisms remaining inadequately understood. Animal models serve as essential tools for investigating disease progression and evaluating treatment options. This article reviews the advancements in research involving animal models, including nonhuman primates and rodents, in the development of EMS-related infertility models. This study provides a comprehensive overview of the latest advancements in understanding the mechanisms of infertility related to EMS in animal models. It serves as a valuable resource for researchers seeking guidance in choosing suitable animal models for investigations on the pathogenesis and pharmacological treatment of this condition.

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Condition tags

endometriosisinfertility

MeSH descriptors

Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

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