Endometriosis and ovulatory disorder: reduced fertilisation in vitro compared with tubal and unexplained infertility

Peter G. Wardle, Wardle PG, P G Wardle, J D Mitchell, Mitchell JD, Alan McDermott, E A McLaughlin, Eileen A. McLaughlin, B D Ray, Ray BD, A McDermott, McDermott A, Hull MG, M.G.R. Hull, M G Hull
Lancet (London, England) · 1985 · vol. 326(8449) , pp. 236–239 · doi:10.1016/s0140-6736(85)90289-2 · PMID:2862417 · W1991787564
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This study compared in vitro fertilization outcomes in women with endometriosis, ovulatory disorders, tubal infertility, or unexplained infertility, finding reduced fertilization rates in the endometriosis and ovulatory disorder groups.

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Abstract

In-vitro fertilisation (IVF) was carried out once for each of 104 couples who had a single cause of infertility. The group with tubal damage was used as the reference for normal fertilising capacity of both oocytes and sperms: the IVF rates were 68% (71/105) per mature oocyte and 88% (37/42) for couples from whom mature oocytes were recovered. Couples with poor sperm/mucus penetration had reduced IVF rates: 32% (12/38) per oocyte and 60% (9/15) per couple. Sperm function, which was judged normal by means of standard seminal analysis and mucus penetration, was confirmed by normal IVF in unexplained infertility: 63% (37/59) per oocyte and 90% (18/20) per couple. Despite favourable sperm function in their partners, women with endometriosis (without tubal damage) had reduced IVF rates: 33% (19/58) per oocyte and 60% (9/15) per couple. These findings indicate that ovulatory disorder is present in endometriosis and suggest that it causes the associated infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Fertilization in Vitro Fertilization in Vitro Infertility, Female Adult Adult Age Factors Age Factors Embryo Transfer Embryo Transfer Endometriosis Endometriosis Female Female Humans Humans Infertility, Female Infertility, Female Male Male

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (29)

Cited by (50)

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