Emerging therapy for endometriosis

Sarah F. Lindsay, Danielle E Luciano, D. Luciano, Luciano DE, Anthony A. Luciano, Luciano AA
Expert opinion on emerging drugs · 2015 · vol. 20(3) , pp. 449–461 · doi:10.1517/14728214.2015.1051966 · PMID:26050551 · W1916637586
Review OA: closed CC0 ⤵ 29 in-corpus citations
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This review discusses current endometriosis medical therapies, their limitations, and emerging treatments like GnRH antagonists and aromatase inhibitors combined with hormonal contraceptives.

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Abstract

INTRODUCTION: Endometriosis is a chronic disease manifested by pain and infertility due to ectopic implantation of endometrial glands and stroma causing inflammation. Treatment of endometriosis utilizes a significant amount of health-care resources and requires chronic therapy. Management involves a combination of surgical and medical interventions and requires long-term treatment to avoid repeated surgeries. AREAS COVERED: Whereas medical therapies exist for management of endometriosis-related pain, each class has its limitations including side effects, cost, and known duration of relief of symptoms. Development of effective, well-tolerated medical therapies that are appropriate for long-term use is crucial to provide adequate treatment for this chronic disease. This review discusses the various medical therapies available, their limitations, and emerging therapies being developed to address many of these concerns. EXPERT OPINION: The authors recommend chronic suppressive therapy for management of endometriosis symptoms, particularly in the postoperative setting. Empiric treatment is appropriate for those patients without evidence of severe disease. Currently available option may not be effective for nor tolerated by all patients. Newer compounds, including gonadotropin-releasing antagonists and aromatase inhibitors combined with hormonal contraceptives, offer possible alternatives to currently available therapies.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Pain Management Animals Animals Combined Modality Therapy Combined Modality Therapy Drug Design Drug Design Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Infertility, Female Infertility, Female Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (69)

Cited by (29)

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