Does presence of adenomyosis affect reproductive outcome in IVF cycles? A retrospective analysis of 973 patients

Sunita Sharma, Shikha Bathwal, Bathwal S, Agarwal N, Nupur Agarwal, Ratna Chattopadhyay, Chattopadhyay R, Indranil Saha, Saha I, Baidyanath Chakravarty, Chakravarty B
Reproductive BioMedicine Online · 2018 · vol. 38(1) , pp. 13–21 · doi:10.1016/j.rbmo.2018.09.014 · PMID:30446308 · W2898139482
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This retrospective analysis of 973 IVF patients found that the presence of adenomyosis is associated with a lower clinical pregnancy rate and a higher early miscarriage rate.

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Abstract

RESEARCH QUESTION: Reports on the effect of adenomyosis on assisted reproductive technology (ART) outcomes are conflicting. Does presence of adenomyosis affect reproductive outcome in IVF cycles in women pretreated with gonadotrophin releasing hormone (GnRH) agonist? DESIGN: In this retrospective cohort study, 973 women were divided into four groups: only endometriosis (n = 355); endometriosis and adenomyosis (n = 88); adenomyosis alone (n = 64); and tubal factor infertility as controls (n = 466). The pregnancy outcome parameters (clinical pregnancy, miscarriage rate, live birth rate) were compared between these groups. RESULTS: The clinical pregnancy rate was 36.62% in women with endometriosis alone, 22.72% in women with endometriosis and adenomyosis, 23.44% in women who only had adenomyosis and 34.55% in controls. Miscarriage rates were as follows: 14.62%, 35%, 40% and 13.04%, respectively. Live birth rates were 27.47% in controls; 26.48% in women with only endometriosis; 11.36% in women with endometriosis and adenomyosis; and 12.5% in women with only adenomyosis. Live birth was observed to be less in adenomyosis groups compared with controls and women with only endometriosis. No significant difference was observed in clinical pregnancy, miscarriage or live birth rate between controls and women with only endometriosis. Live birth rate was significantly different between controls and women with adenomyosis only (P = 0.01) and women with endometriosis and adenomyosis (P = 0.002). CONCLUSION: Presence of adenomyosis seems to have adverse effects on IVF outcomes in clinical pregnancy rate, live birth rate and miscarriage rate. Screening for adenomyosis might be considered before ART so that the couple has better awareness of the prognosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Endometriosis Fertilization in Vitro Fertilization in Vitro Infertility, Female Pregnancy Rate Pregnancy Rate Adenomyosis Adenomyosis Adult Adult Birth Rate Birth Rate Endometriosis Endometriosis Female Female Humans Humans Infertility, Female

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