The treatment of endometriosis with Danazol

Friedlander Rl, R L Friedlander
The Journal of reproductive medicine · 1973 · vol. 10(4) , pp. 197–9 · PMID:4266628 · W2296163246
Non-randomised trial OA: closed CC0 ⤵ 40 in-corpus citations
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Danazol therapy for 43 endometriosis patients resulted in pain relief for most, pregnancy for 9 infertile patients, and remission of endometriosis in 31, with weight gain as the most common side effect.

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Abstract

43 patients with well-documented pelvic endometriosis were treated with a new anti-gonadotropic steroid compound danazol. The patients could be put in 2 general categories: those who were infertile who may or may not have had other significant lesion related symptoms and those who were seeking symptomatic relief only. After confirmation of the presence of endometriosis baseline laboratory studies were performed and danazol in an oral dose of 800 mg daily was administered for 6 months. Each patient was seen at 4-week intervals for historical review physical examination and a series of laboratory test. At the end of 6 months laparoscopy or laparotomy was performed and the effect of treatment documented. Patients were observed thereafter at regular intervals especially for the return of ovulatory function. 39 of the initial 43 patients completed the program. Of 28 patients seeking pain relief 21 had complete remission and 5 noted improvement. Of 22 previously infertile patients 9 have achieved pregnancy. On objective examination during laparotomy or laparoscopy no evidence of endometriosis was demonstrable in 31 patients; the pelvic organs were essentially normal. In 6 patients partial improvement was noted. The most commonly noted side effect of danazol therapy is weight gain. There were also cases of irregular bleeding mild acneform rash and 1 patient described a very subtle increase in hair growth on the face and extremities. Allergy conjunctival edema depression blurred vision and flu syndrome also arose during therapy although their relationship to danazol administration was questionable.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Pregnadienes Acne Vulgaris Acne Vulgaris Acne Vulgaris Adult Adult Alkynes Alkynes Alkynes Alkynes Drug Hypersensitivity Drug Hypersensitivity Edema Edema Edema Endometriosis Endometriosis Endometriosis Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (38)

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