TREATMENT OF ENDOMETRIOSIS: A STUDY OF MEDICAL MANAGEMENT

A D Noble, A T Letchworth
British journal of obstetrics and gynaecology · 1980 · vol. 87(8) , pp. 726–728 · doi:10.1111/j.1471-0528.1980.tb04607.x · PMID:7426534 · W2025115790
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Danazol treatment for endometriosis was better tolerated and showed superior improvement in symptoms, signs, and fertility compared to Enavid, though neither medical therapy benefited patients with severe disease.

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Abstract

Fifty patients with endometriosis were treated with hormones: 27 with danazol and 23 with Enavid (mestranol 75 micrograms and norethynodrel 5 mg). Side effects were more common and potentially more serious in the group treated with Enavid. Fewer women completed treatment with Enavid and their physical signs showed little improvement. Danazol was better tolerated and the results of treatment, as judged by improvement of symptoms or signs and in future fertility rates, were superior to those recorded in the Enavid treated group. Patients with large endometriotic cysts or severe fibrosis did not benefit from medical treatment. Danazol treatment appeared helpful for women who had mild or moderate endometriotic disease. It may be used alone or as a complimentary treatment after conservative surgical operations.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Mestranol Norethynodrel Pregnadienes Uterine Neoplasms Adult Danazol Danazol Drug Combinations Endometriosis Female Humans Infertility, Female Infertility, Female Mestranol Mestranol Norethynodrel Norethynodrel Pregnadienes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (3)

Cited by (13)

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