Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis.

Arimoto T, Takahide Arimoto, Toyomasa Katagiri, Katagiri T, Oda K, Katsutoshi Oda, Tatsuhiko Tsunoda, Tsunoda T, Toshiharu Yasugi, Yasugi T, Osuga Y, Yutaka Osuga, Yoshikawa H, Hiroyuki Yoshikawa, Nishii O, Osamu Nishii, Tetsu Yano, Yano T, Taketani Y, Yuji Taketani, Yusuke Nakamura, Nakamura Y
International journal of oncology · 2003 · vol. 22(3) , pp. 551–60 · PMID:12579308 · W1840030316
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This study analyzed gene-expression profiles of ovarian endometrial cysts using cDNA microarrays, identifying numerous up-regulated and down-regulated genes compared to eutopic endometria.

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Abstract

Using a cDNA microarray consisting of 23,040 genes, we analyzed gene-expression profiles of ovarian endometrial cysts from 23 patients in order to identify genes involved in endometriosis. By comparing expression patterns between endometriotic tissues and corresponding eutopic endometria, we identified 15 genes that were commonly up-regulated in the endometrial cysts during both proliferative and secretory phases of the menstrual cycle, 42 that were up-regulated only in the proliferative phase, and 40 that were up-regulated only in the secretory phase. The up-regulated elements included genes encoding some HLA antigens, complement factors, ribosomal proteins, and TGFBI. On the other hand, 337 genes were commonly down-regulated throughout the menstrual cycle, 144 only in the proliferative phase, and 835 only in the secretory phase. The down-regulated elements included the tumor suppressor TP53, genes related to apoptosis such as GADD34, GADD45A, GADD45B and PIG11, and the gene encoding OVGP1, a protein involved in maintenance of early pregnancy. Semi-quantitative RT-PCR experiments supported the results of our microarray analysis. These data should provide useful information for finding candidate genes whose products might serve as molecular targets for diagnosis or treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

DNA, Complementary Endometriosis Gene Expression Profiling Oligonucleotide Array Sequence Analysis Ovarian Cysts Ovarian Diseases Adult Apoptosis Apoptosis DNA, Complementary Endometriosis Epithelial Cells Epithelial Cells Expressed Sequence Tags Female Gene Expression Regulation Genes, MHC Class II Humans Menstrual Cycle Ovarian Cysts

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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