Levels of Antibodies to Transferrin and Alpha 2‐HS Glycoprotein in Women With and Without Endometriosis

S P Mathur, Mathur SP, Subbi Mathur, V L Holt, Holt VL, Philip F. Rust, Victoria L. Holt, Lee JH, J H Lee, H Jiang, Haixiang Jiang, Jiang H, Jong Hoon Lee, P. F. Rust, Rust PF
American journal of reproductive immunology (New York, N.Y. : 1989) · 1998 · vol. 40(2) , pp. 69–73 · doi:10.1111/j.1600-0897.1998.tb00393.x · PMID:9764347 · W2055433621
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An ELISA revealed that women with endometriosis had significantly higher levels of antibodies to transferrin and alpha 2-HS glycoprotein compared to control subjects.

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Abstract

PROBLEM: To establish an enzyme-linked immunosorbent assay (ELISA) for determining the levels of antibodies to transferrin and alpha 2-HS glycoprotein in the serum of women with and without endometriosis. METHOD OF STUDY: Serum samples were obtained from 105 normal women, who were randomly selected for a population-based epidemiologic study, and 123 patients with active endometriosis. An ELISA using transferrin and alpha 2-HS glycoprotein as antigens was established. RESULTS: The levels of antibodies to transferrin and alpha 2-HS glycoprotein in the serum of patients with endometriosis were approximately 21 times higher than those in the serum of control subjects without endometriosis. Only 2% of control subjects had false positive levels of these antibodies, and 5% of patients with endometriosis had false negative levels of these antibodies (specificity, 98.1 and 98.1, respectively, for anti-transferrin and anti-alpha 2-HS glycoprotein; sensitivity, 95 and 96.7, respectively, for anti-transferrin and anti-alpha 2-HS glycoprotein). CONCLUSIONS: Patients with endometriosis have significantly higher levels of antibodies to transferrin and alpha 2-HS glycoprotein than control subjects. Testing women for antibodies to transferrin and alpha 2-HS glycoprotein will provide a specific noninvasive diagnosis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Antibodies Blood Proteins Endometriosis Enzyme-Linked Immunosorbent Assay Transferrin Adolescent Adult alpha-2-HS-Glycoprotein Antibodies Blood Proteins Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Middle Aged Transferrin

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