Paracrine regulation of matrix metalloproteinase expression in the normal human endometrium

Osteen KG, Kevin G. Osteen, K. G. Osteen, N R Keller, Nancy R. Keller, Keller NR, F A Feltus, F. Alex Feltus, Feltus FA, Michael H. Melner, M H Melner, Melner MH
Gynecologic and obstetric investigation · 1999 · vol. 48(Suppl. 1) , pp. 2–13 · doi:10.1159/000052863 · PMID:10559659 · W2030973262
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This study investigated how paracrine factors like TGF-beta and retinoic acid, along with progesterone, regulate endometrial matrix metalloproteinase expression, finding altered regulation at ectopic sites relevant to endometriosis.

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Abstract

Endometrial expression of matrix metalloproteinase (MMP)-3, MMP-7 and MMP-11 occurs during menstrual breakdown and subsequent estrogen-mediated growth, but not during the secretory phase. These enzymes are suppressed by progesterone treatment. Paracrine factors, including transforming growth factor-beta (TGF-beta) and retinoic acid, are also critical for MMP regulation in the endometrium. In contrast, inflammatory cytokines such as interleukin-1alpha may block or interfere with steroid-mediated MMP regulation at ectopic sites of growth. Using in vitro models, our laboratory has investigated the complex interactions between progesterone and locally produced cytokines that may affect MMP expression during the development of endometriosis. Our results indicate that targeting the regulation of MMPs may represent an appropriate therapeutic strategy for the treatment of endometriosis. Copyrightz1999S. KargerAG,Basel

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Regulation, Enzymologic Gene Expression Regulation, Enzymologic Matrix Metalloproteinases Adult Adult Blotting, Western Blotting, Western Chromatography, Thin Layer Chromatography, Thin Layer Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (42)

Cited by (50)

Source provenance

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