Oxidative stress and endometriosis

Leila W. Jackson, L W Jackson, Jackson LW, E F Schisterman, Enrique F. Schisterman, Dey-Rao R, Rama Dey-Rao, R Dey-Rao, Richard W. Browne, Browne R, R Browne, Armstrong D, D Armstrong, Donald Armstrong
Human Reproduction · 2005 · vol. 20(7) , pp. 2014–2020 · doi:10.1093/humrep/dei001 · PMID:15817589 · W2170129839
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This study measured four markers of oxidative stress and antioxidant status in serum for 61 women undergoing laparoscopy and found a weak association between thiobarbituric acid-reactive substances and endometriosis.

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Abstract

BACKGROUND: Little is known about the aetiology of endometriosis; however, in the presence of oxidative stress, reactive oxygen species might increase growth and adhesion of endometrial cells in the peritoneal cavity, leading to endometriosis and infertility. Within a study investigating persistent organic compounds and endometriosis, the authors evaluated the association between oxidative stress and endometriosis. METHODS: Women aged 18-40 years who were undergoing laparoscopy were contacted to participate in the study (n = 100); 84 were eligible and agreed to be interviewed; 78 provided blood specimens. Four markers of oxidative stress and antioxidant status were measured in serum for 61 women. Multiple imputation of missing data was used to generate values for the missing oxidative stress data. RESULTS: Thirty-two women had visually confirmed endometriosis at laparoscopy while 52 did not, including 22 undergoing tubal ligation and 30 with idiopathic infertility. There was a weak association between thiobarbituric acid-reactive substances (nmol/ml) and endometriosis, after adjusting for age, body mass index, current smoking, hormone use in the past 12 months, gravidity, serum vitamin E, serum estradiol, and total serum lipids (beta = 1.18; 95% CI-0.04, 2.39). CONCLUSIONS: These results suggest that oxidative stress might play a role in the development and progression of endometriosis, which should be evaluated in larger studies.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Oxidative Stress Oxidative Stress Adolescent Adolescent Adult Adult Antioxidants Antioxidants Antioxidants Aryldialkylphosphatase Aryldialkylphosphatase Aryldialkylphosphatase Biomarkers Biomarkers Biomarkers Dinoprost Dinoprost Dinoprost

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (45)

Cited by (50)

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