OBJECTIVE: To provide a framework for conducting rigorous nonrandomized studies of interventions in fertility treatment research, addressing their role as complements to randomized controlled trials (RCTs) in evaluating treatment outcomes. …
OBJECTIVE: To characterize variation in circulating vascular endothelial growth factor (VEGF) and its receptor, soluble fms-like tyrosine kinase-1 (sFLT-1), across the menstrual cycle in normal ovulating women in relation to reproductive ho…
ObjectiveTo estimate the effect of daily 81 mg low-dose aspirin (LDA) on menstrual cycle length and hormone profiles.DesignSecondary analysis of a trial evaluating the effect of daily LDA or placebo on live birth among women with one or two…
BackgroundVitamin D deficiency during pregnancy is associated with adverse pregnancy outcomes, although the association between preconception vitamin D concentrations and livebirth is unknown. We aimed to assess the association between prec…
ObjectiveTo assess systemic inflammation in relation to fecundability and anovulation.DesignProspective cohort study among participants in the Effects of Aspirin in Gestation and Reproduction trial who were assigned to the placebo.SettingAc…
BackgroundLittle is known about the associations of bisphenol A, chlorophenols, benzophenones, and parabens with reproductive hormone levels in women. Our goal was to evaluate the associations between repeated measures of these chemicals an…
BackgroundPrior studies have reported mixed results regarding relationships between vitamin D, androgens, and sex hormone-binding globulin in patients with polycystic ovary syndrome. However, less is known regarding these associations in eu…
ContextInflammation is linked to causes of infertility. Low-dose aspirin (LDA) may improve reproductive success in women with chronic, low-grade inflammation.ObjectiveTo investigate the effect of preconception-initiated LDA on pregnancy rat…
BackgroundOvert thyroid dysfunction has been associated with adverse obstetric outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications.ObjectiveThe purp…
ObjectiveTo evaluate if antimüllerian hormone (AMH) is associated with pregnancy loss.DesignProspective cohort study within a block-randomized, double-blind, placebo-controlled trial of low-dose aspirin.SettingNot applicable.Patient(s)Women…
PurposeThe purpose of this study is to characterize the patterns of medication intake in healthy, reproductive-age women not using hormonal contraception.MethodsTwo hundered fifty-nine healthy, premenopausal women (18-44 years of age) enrol…
BackgroundEvidence is growing that the equilibrium between reactive oxygen species and antioxidants plays a vital role in women's reproductive health.ObjectiveThe objective of this study was to evaluate variations in serum antioxidant conce…
ContextPrior studies examining associations between subclinical hypothyroidism and antithyroid antibodies with early pregnancy loss and live birth suggest mixed results and time to pregnancy (TTP) has not been studied in this patient popula…
STUDY QUESTION: Does use of commonly used over-the-counter (OTC) pain medication affect reproductive hormones and ovulatory function in premenopausal women? SUMMARY ANSWER: Few associations were found between analgesic medication use and re…
ObjectiveThe objective of the study was to evaluate whether anti-Müllerian hormone (AMH) is associated with fecundability among women with proven fecundity and a history of pregnancy loss.DesignThis was a prospective cohort study within a m…
Study questionDoes serum anti-Müllerian hormone (AMH) vary significantly throughout both ovulatory and sporadic anovulatory menstrual cycles in healthy premenopausal women?Summary answerSerum AMH levels vary statistically significantly acro…
PurposeTo determine whether depressive symptoms are associated with ovulation or reproductive hormone concentrations in eumenorrheic women without a reported diagnosis of clinical depression.MethodsA prospective cohort of 248 regularly mens…
ContextAlthough adequate luteal hormone production is essential for establishing pregnancy, luteal phase deficiency (LPD) is poorly characterized among eumenorrheic women.ObjectiveWe assessed the prevalence and overlap of two established LP…
RATIONALE AND OBJECTIVES: Biomarkers are of ever-increasing importance to clinical practice and epidemiologic research. Multiple biomarkers are often measured per patient. Measurement of true biomarker levels is limited by laboratory precis…