The Relationship of Oxidative Stress and Inflammatory Response in Females Associated with Endometriosis

Sumera Noor, Muhammad Tahir, Mateen-Ur- Rehman, Bushra Sayyed, Shahid Noor, Jan Ubaidullah, Tahir Maqbool, Rana Muhammad Athar Azeem Shams
In: Pak-Euro Journal of Medical and Life Sciences · 2022 · vol. 5(2) , pp. 345–350 · doi:10.31580/pjmls.v5i2.2523 · W4312442364
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that women with endometriosis exhibit disrupted hematological profiles, increased oxidative stress markers (MDA), reduced antioxidant gene expression (SOD, GSH, CAT), and lower vitamin levels compared to healthy controls.

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Abstract

Endometriosis is considered as debilitating condition that characterized by formation of endometrial tissue outside the uterus that consequently adversely impact the female fertility. Number of factors are involved that mediates the gynecological pathology of endometriosis, however the relationship of endometriosis with oxidative stress and inflammatory need to investigate. In this study, we selected female of age 21-27 years associated with endometriosis and performed detailed hematological profile. Our data indicated that the hematological profile of patients associated with endometriosis was highly disrupted compared to healthy control females. Number of hematological parameters including RBCs, WBCs, HB, platelets and overall bilirubin level was abnormal in endometritis patients. In addition, we also determined the level of oxidative stress by using the expression profile of different oxidant and anti-oxidant genes through spectrophotometric examination. We found elevated level of MDA and reduced expressions of SOD, GSH, and CAT in patients associated with endometriosis relative to healthy patients that suggest the increased oxidative stress level. Furthermore, different vitamins including, VIT A, VIT C, VIT E, and VIT D level was also reduced in patients of endometriosis. Collectively, our data suggest that hematological profile and oxidative stress of patients associated with endometriosis was highly disruptive and these differential biomarkers may be the useful to diagnose the endometriosis patients and also beneficial for developing treatment strategies.

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endometriosis

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