Suppression of natural killer cell activity by splenocyte transplantation in a rat model of endometriosis

Hirotaka Ota, Ota H, Rong H, Huang Rong, Igarashi S, Shinichi Igarashi, Tanaka T, Toshinobu Tanaka
Human Reproduction · 2002 · vol. 17(6) , pp. 1453–1458 · doi:10.1093/humrep/17.6.1453 · PMID:12042260 · W2155647556
Lab / animal OA: closed CC0 ⤵ 9 in-corpus citations
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Endometriosis rat models receiving splenocyte injections showed suppressed natural killer cell activity and reduced NK cell numbers compared to control groups.

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Abstract

BACKGROUND: One immune characteristic of endometriosis is a decrease in natural killer (NK) cell activity. This study was performed to determine whether an abnormal immune reaction in an endometriosis animal model could be transferred to an animal of the same species. METHODS: An endometriosis model was prepared using 8 week old female rats by grafting a small section of one uterine horn onto the mesentery, followed 4 weeks later by removal of the spleen and remaining uterine horn. Splenocytes, that had been depleted of macrophages were injected via the tail vein, and NK cell activity of splenocytes was determined 4 days later. The uterus was simultaneously investigated immunohistochemically for immune cells. There was a control group (untreated; group 1), a control-splenocyte injection group (group 2), an experimental endometriosis model group (group 3) and an endometriosis model splenocyte injection group (group 4). RESULTS: Splenocyte NK cell activity was decreased in group 3 to 42.0% of that of group 1 and in group 4 to 38.9%. Immunohistologically, the number of NK cells in groups 3 and 4 markedly decreased to 62.0 and 55.1% of group 1 respectively. CONCLUSION: It was demonstrated that abnormal immunity caused by allograft of immune cells could recur in an endometriosis rat model.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Killer Cells, Natural Spleen Adoptive Transfer Adoptive Transfer Animals Animals Cytotoxicity, Immunologic Cytotoxicity, Immunologic Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (32)

Cited by (9)

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