Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis

J Punnonen, Punnonen J, Juha Punnonen, Teisala K, Klaus Teisala, K Teisala, Hannu Ranta, H Ranta, Ranta H, Bruce Bennett, B Bennett, Bennett B, Punnonen R, R. Punnonen
American journal of obstetrics and gynecology · 1996 · vol. 174(5) , pp. 1522–1526 · doi:10.1016/s0002-9378(96)70600-2 · PMID:9065123 · W2032502860
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This study investigated the concentrations of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis and found increased levels of both cytokines.

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Abstract

OBJECTIVE: The levels of interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-10, and granulocyte-macrophage colony-stimulating factor were measured in the peritoneal fluid of 15 patients with endometriosis to characterize the type of immune response that occurs at the site of endometriosis. STUDY DESIGN: Cytokine levels in peritoneal fluid obtained during laparoscopy from 15 patients and 12 controls undergoing tubal ligation were determined by enzyme-linked immunosorbent assay. RESULTS: The mean levels of interleukin-6 in patients with endometriosis and controls were 797 +/- 407 pg/ml and 133 +/- 38 pg/ml, respectively (p < 0.02). Similarly, the mean concentration of interleukin-10 in peritoneal fluids of patients with endometriosis was significantly higher than that of controls (241 +/- 38 vs 128 +/- 21, p < 0.05). The levels of interleukin-2, interleukin-4, interleukin-5, and granulocyte-macrophage colony-stimulating factor were not significantly different between the two study groups. CONCLUSIONS: The levels of interleukin-6 and interleukin-10 are increased in the peritoneal fluids of patients with endometriosis, suggesting enhanced macrophage activity in these patients. Increased interleukin-6 and interleukin-10 production may partially contribute to the disturbed immune regulation observed in patients with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-10 Interleukin-6 Adult Adult Ascitic Fluid Ascitic Fluid Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female Female Granulocyte-Macrophage Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Humans Humans Interleukin-10

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (29)

Cited by (50)

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