Targeting mast cells: a new way to treat endometriosis

Maria Mercedes Binda, María Mercedes Binda, Jacques Donnez, Donnez J, Dolmans MM, Marie‐Madeleine Dolmans, Marie-Madeleine Dolmans
Expert opinion on therapeutic targets · 2016 · vol. 21(1) , pp. 67–75 · doi:10.1080/14728222.2017.1260548 · PMID:27841046 · W2555073431
Review OA: closed CC0 ⤵ 45 in-corpus citations
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This review summarizes preclinical and clinical findings demonstrating increased mast cells in endometriosis, suggesting mast cell stabilizers and inhibitors as potential therapeutic targets for the disease and its associated pain.

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Abstract

Endometriosis is a chronic estrogen-dependent inflammatory disease of unclear etiology that affects 15-20% of women of reproductive age. Efforts are now focusing on understanding new mechanisms involved in its physiopathology, like novel target pathways and different molecules. There is evidence that mast cells (MCs) play a role in this disease. This article summarizes recent achievements in preclinical studies and clinical activities investigating the role of MCs in endometriosis. Targeting MCs might offer new alternatives to treat this disease. Areas covered: A systematic literature search was performed (PubMed, Cochrane Library and ClinicalTrials.gov) using the keywords 'endometriosis and mast cells'. All relevant articles (34) found in PubMed were examined and their reference lists reviewed in order to pinpoint further studies for potential inclusion. Expert opinion: Since endometriosis is a multifactorial disease, and considering that numbers of MCs and activated MCs were clearly increased in endometriotic lesions in both animals and humans, use of MC stabilizers and inhibitors may prove to be effective to treat endometriosis and its associated pain. However, more data from preclinical studies and clinical trials will help to better define the status of MCs in the treatment of this pathology.

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Condition tags

endometriosis

MeSH descriptors

Drug Design Drug Design Endometriosis Mast Cells Animals Animals Endometriosis Endometriosis Endometriosis Estrogens Estrogens Estrogens Female Female Humans Humans Mast Cells Mast Cells Mast Cells Molecular Targeted Therapy

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (97)

Cited by (49)

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License: CC0 · commercial use OK