Exploring the Endocrine Mechanisms in Adenomyosis: From Pathogenesis to Therapies
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This review examines the pathogenesis of adenomyosis, focusing on dysregulated sex-steroid hormones, the potential role of endocrine disruptors, and genetic/epigenetic alterations in its development and progression.
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Abstract
Adenomyosis (ADM) is a multifaceted uterine pathology characterized by the ectopic infiltration of endometrial tissue into the myometrium, afflicting approximately 20% of women in the reproductive age group seeking gynecological care. This condition manifests as a range of debilitating symptoms, including dysmenorrhea, menorrhagia, impaired fertility, and heightened susceptibility to miscarriage and obstetric complications. Substantial research has been dedicated to exploring its underlying molecular mechanisms and developing non-invasive precision medical therapies. ADM is primarily characterized by a dysregulation in sex-steroid hormone homeostasis, particularly estrogen and progesterone. However, emerging evidence suggests that additional endocrine mediators and disruptors may exert contributory roles in the etiology of ADM. Furthermore, genetic and epigenetic alterations of endocrine signaling pathways have been implicated as prevailing mechanisms underlying the development and progression of the disease. The present review aims to provide an updated and comprehensive overview of the current understanding of the pathophysiology of ADM, with a particular emphasis on the dysregulated hormonal milieu and the potential involvement of endocrine disruptors. By elucidating these intricate molecular mechanisms, this review seeks to pave the way for novel research directions in the development of targeted therapeutic strategies for ADM management.
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References (100)
- Aberrant immunoreactivity of deoxyribonucleic acid methyltransferases in adenomyosis via openalex
- Absence of aromatase protein and mRNA expression in endometriosis via openalex
- Additive effects of inflammation and stress reaction on Toll-like receptor 4-mediated growth of endometriotic stromal cells via openalex
- Adenomyosis and endometriosis in the California Teachers Study via openalex
- Adenomyosis: genetics of estrogen metabolism via openalex
- Adenomyosis in mice resulting from mechanically or thermally induced endometrial-myometrial interface disruption and its possible prevention via openalex
- Adenomyosis: Mechanisms and Pathogenesis via openalex
- Adenomyosis pathogenesis: insights from next-generation sequencing via openalex
- Adenomyosis: the pathophysiology of an oestrogen-dependent disease via openalex
- A new concept of endometriosis and adenomyosis: tissue injury and repair (TIAR) via openalex
- A new trick for an old dog: The application of mifepristone in the treatment of adenomyosis via openalex
- Animal Models of Adenomyosis via openalex
- An irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 inhibits estradiol synthesis in human endometriosis lesions and induces regression of the non-human primate endometriosis via openalex
- Association between phthalate exposure and glutathione S-transferase M1 polymorphism in adenomyosis, leiomyoma and endometriosis via openalex
- Association of phthalate esters with endometriosis in Indian women via openalex
- Associations between persistent organic pollutants and endometriosis: A multiblock approach integrating metabolic and cytokine profiling via openalex
- Biological differences between intrinsic and extrinsic adenomyosis with coexisting deep infiltrating endometriosis via openalex
- Bromocriptine inhibits proliferation in the endometrium from women with adenomyosis via openalex
- Celecoxib, a selective COX-2 inhibitor, markedly reduced the severity of tamoxifen-induced adenomyosis in a murine model via openalex
- Changes in adenomyosis after treatment with ulipristal acetate via openalex
- Changes in the concentrations of receptors of insulin-like growth factor-I, epithelial growth factor, oestrogens and progestagens in adenomyosis foci, endometrium and myometrium of women during menstrual cycle via openalex
- Clinical usefulness of determination of estradiol level in the menstrual blood for patients with endometriosis via openalex
- Comparison of dienogest versus combined oral contraceptive pills in the treatment of women with adenomyosis: A randomized clinical trial via openalex
- Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis via openalex
- Developmental Toxicant Exposure Is Associated with Transgenerational Adenomyosis in a Murine Model via openalex
- Diagnosing adenomyosis: an integrated clinical and imaging approach via openalex
- Diagnosis and initial management of dysmenorrhea via openalex
- Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis via openalex
- Early-life factors and endometriosis risk via openalex
- Effect of Mifepristone vs Placebo for Treatment of Adenomyosis With Pain Symptoms: A Randomized Clinical Trial via openalex
- Effects of mifepristone (RU486) treatment on the development of uterine adenomyosis induced by pituitary grafting in mice via openalex
- Effects of prenatal exposure of mice to "low-dose" diethylstilbestrol and the development of adenomyosis associated with evidence of hyperprolactinemia via openalex
- Elevated immunoreactivity against class I histone deacetylases in adenomyosis via openalex
- Endometrial regeneration and endometrial stem/progenitor cells via openalex
- Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review via openalex
- Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin via openalex
- Epidemiology of Adenomyosis via openalex
- Estrogen 17β‑estradiol accelerates the proliferation of uterine junctional zone smooth muscle cells via the let‑7a/Lin28B axis in adenomyosis via openalex
- Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis via openalex
- Estrogen biosynthesis in human uterine adenomyosis via openalex
- Evidence for estrogen synthesis in adenomyotic tissues via openalex
- Evolution of uterine adenomyosis volume during and after GnRH antagonist (linzagolix) treatment: lessons for further clinical trials via openalex
- Exosomes: potential diagnostic markers and drug carriers for adenomyosis via openalex
- Exploring the Endocrine Mechanisms in Adenomyosis: From Pathogenesis to Therapies via openalex
- Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models via openalex
- Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium via openalex
- Expression of oxytocin receptors in the uterine junctional zone in women with adenomyosis via openalex
- Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification via openalex
- Functional characterization of somatic point mutations of the human estrogen receptor alpha (hERalpha) in adenomyosis uteri via openalex
- Functional Implications of Estrogen and Progesterone Receptors Expression in Adenomyosis, Potential Targets for Endocrinological Therapy via openalex
- High frequency of adenomyosis in postmenopausal breast cancer patients treated with tamoxifen via openalex
- High plasma concentrations of polychlorinated biphenyls and phthalate esters in women with endometriosis: a prospective case control study via openalex
- History of adenomyosis via openalex
- Introduction: Uterine adenomyosis, another enigmatic disease of our time via openalex
- Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? via openalex
- Levonorgestrel-releasing intrauterine system versus a low-dose combined oral contraceptive for treatment of adenomyotic uteri: a randomized clinical trial via openalex
- m6A RNA Methylation Regulators Contribute to Eutopic Endometrium and Myometrium Dysfunction in Adenomyosis via openalex
- Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis via openalex
- Mechanisms and Pathogenesis of Adenomyosis via openalex
- Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis via openalex
- microRNA Let-7b: A Novel treatment for endometriosis via openalex
- MR imaging of diffuse adenomyosis changes after GnRH analog therapy via openalex
- New Sonographic Classification of Adenomyosis: Do Type and Degree of Adenomyosis Correlate to Severity of Symptoms? via openalex
- Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice via openalex
- Pathogenesis of adenomyosis: an update on molecular mechanisms via openalex
- Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility via openalex
- Pathogenesis of uterine adenomyosis: invagination or metaplasia? via openalex
- Pathology and Pathogenesis of Adenomyosis via openalex
- Perfluorochemicals and endometriosis: the ENDO study via openalex
- Phthalates and risk of endometriosis via openalex
- Possible Loss of GABAergic Inhibition in Mice With Induced Adenomyosis and Treatment With Epigallocatechin-3-Gallate Attenuates the Loss With Improved Hyperalgesia via openalex
- Possible roles of oxytocin receptor and vasopressin-1α receptor in the pathomechanism of dysperistalsis and dysmenorrhea in patients with adenomyosis uteri via openalex
- Pre-natal exposure of mice to bisphenol A elicits an endometriosis-like phenotype in female offspring via openalex
- Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium via openalex
- Prolactin role in the bovine uterus during adenomyosis via openalex
- Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent via openalex
- Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes via openalex
- Reproductive Outcomes after Fertility-Sparing Surgery for Focal and Diffuse Adenomyosis: A Systematic Review via openalex
- Risk factors for adenomyosis via openalex
- Risk for estrogen-dependent diseases in relation to phthalate exposure and polymorphisms of CYP17A1 and estrogen receptor genes via openalex
- Shorter Anogenital Distance in Women with Ovarian Endometriomas and Adenomyosis, but Not Uterine Leiomyomas via openalex
- Single-Cell Profiling Uncovers the Roles of Endometrial Fibrosis and Microenvironmental Changes in Adenomyosis via openalex
- Stem Cells in Endometrial Physiology via openalex
- Stimulation of mammary tumorigenesis and suppression of uterine adenomyosis by temporary inhibition of pituitary prolactin secretion during youth in mice (41492) via openalex
- Structural and molecular features of the endomyometrium in endometriosis and adenomyosis via openalex
- Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group via openalex
- The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases via openalex
- The induction of adenomyosis in mice by intrauterine pituitary isografts via openalex
- The Interplay Between Prolactin and Reproductive System: Focus on Uterine Pathophysiology via openalex
- The Pathogenesis of Adenomyosis vis-à-vis Endometriosis via openalex
- The possible role of fluoxetine in adenomyosis: an animal experiment with clinical correlations via openalex
- Therapeutic potential of curcumin in endometrial disorders: Current status and future perspectives via openalex
- The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis via openalex
- Toll-like receptor 4-mediated growth of endometriosis by human heat-shock protein 70 via openalex
- Transforming growth factor β1 signaling coincides with epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis in mice via openalex
- Transmembrane G protein-coupled receptor 30 gene polymorphisms and uterine adenomyosis in Korean women via openalex
- Ultrastructural changes in uterine myometrium of mice with experimentally-induced adenomyosis via openalex
- Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations via openalex
- Uterine stem cells: what is the evidence? via openalex
- Vaginal bromocriptine for treatment of adenomyosis: Impact on magnetic resonance imaging and transvaginal ultrasound via openalex
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