The presence of endometrial cells in the peritoneal cavity enhances monocyte recruitment and induces inflammatory cytokines in mice: implications for endometriosis

Xuan Cao, Cao X, Yang D, Dongzi Yang, Song M, Mingqing Song, Murphy A, Ana Murphy, Ana A. Murphy, Sampath Parthasarathy, Parthasarathy S
Fertility and sterility · 2004 · vol. 82 , pp. 999–1007 · doi:10.1016/j.fertnstert.2004.04.040 · PMID:15474064 · W2074882515
Lab / animal OA: bronze CC0 ⤵ 47 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study found that endometrial cells in the peritoneal cavity of mice promote monocyte recruitment and the release of inflammatory cytokines, suggesting a mechanism for endometriosis development.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To determine the inflammatory response in the peritoneal cavity by the presence of endometrial cells and the role of the mesothelium. DESIGN: In vivo study using mice. SETTING: University research laboratory. ANIMAL(S): Female Swiss Webster mice, 8 to 10 weeks old. INTERVENTION(S): Homogenous mouse endometrial epithelial and stromal cells were injected intraperitoneally. Peritoneal lavage and mesothelium were collected 4 to 72 hours after the administration. MAIN OUTCOME MEASURE(S): We determined the number of peritoneal macrophages, and the production and gene expression of monocyte chemotactic protein-1 (MCP-1/JE), interleukin 1alpha (IL-1alpha), and interleukin 6 (IL-6). RESULT(S): The intraperitoneal administration of endometrial cells increased the number of peritoneal macrophages, production of MCP-l, IL-1alpha, and IL-6, and expression of mesothelial MCP-1/JE, IL-1alpha, and IL-6 genes in recipient mice. CONCLUSION(S): These results suggest that retrograde menstruation could account for the increased presence of inflammatory mediators in the peritoneal cavity of women with endometriosis. The mesothelium could play an active role in endometriosis in addition to providing an attachment stratum for the endometrial cells.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Cytokines Endometrium Inflammation Mediators Monocytes Peritoneal Cavity Peritoneal Cavity Animals Animals Chemokine CCL2 Chemokine CCL2 Chemokine CCL2 Chemokine CCL2 Cytokines Cytokines Endometriosis Endometriosis Endometriosis Endometrium Endometrium Epithelial Cells

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (37)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-17T06:09:56.316927+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:02:47.667321+00:00
License: CC0 · commercial use OK