Macrophage Immune Memory Controls Endometriosis in Mice and Humans

Mohamed Jeljeli, Jeljeli M, Luiza G C Riccio, Luiza Gama Coelho Riccio, Sandrine Chouzenoux, Chouzenoux S, Fabiana Moresi, Laurie Toullec, Ludivine Doridot, Carole Nicco, Mathilde Bourdon, Bourdon M, Marcellin L, Louis Marcellin, Santulli P, Pietro Santulli, Piétro Santulli, Maurício Simões Abrão, Mauricio S Abrão, Abrão MS, Charles Chapron, Chapron C, Batteux F, Frédéric Batteux
Cell reports · 2020 · vol. 33(5) , pp. 108325 · doi:10.1016/j.celrep.2020.108325 · PMID:33147452 · W3085811702
Lab / animal OA: gold CC0 ⤵ 44 in-corpus citations
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Tolerized human macrophages, via IL-10, mitigate endometriosis, and prior Gram-negative infections are linked to improved outcomes in patients.

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Abstract

Endometriosis is a frequent, chronic, inflammatory gynecological disease characterized by the presence of ectopic endometrial tissue causing pain and infertility. Macrophages have a central role in lesion establishment and maintenance by driving chronic inflammation and tissue remodeling. Macrophages can be reprogrammed to acquire memory-like characteristics after antigenic challenge to reinforce or inhibit a subsequent immune response, a phenomenon termed "trained immunity." Here, whereas bacille Calmette-Guérin (BCG) training enhances the lesion growth in a mice model of endometriosis, tolerization with repeated low doses of lipopolysaccharide (LPSlow) or adoptive transfer of LPSlow-tolerized macrophages elicits a suppressor effect. LPSlow-tolerized human macrophages mitigate the fibro-inflammatory phenotype of endometriotic cells in an interleukin-10 (IL-10)-dependent manner. A history of severe Gram-negative infection is associated with reduced infertility duration and alleviated symptoms, in contrast to patients with Gram-positive infection history. Thus, the manipulation of innate immune memory may be effective in dampening hyper-inflammatory conditions, opening the way to promising therapeutic approaches.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Immunologic Memory Immunologic Memory Macrophages, Peritoneal Adoptive Transfer Adoptive Transfer Animals Animals Coculture Techniques Coculture Techniques Cytokines Cytokines Cytokines Endometriosis Endometriosis Endometriosis Female Female Gram-Negative Bacterial Infections

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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