Serial laparoscopies over 30 months show that endometriosis in captive baboons (Papio anubis, Papio cynocephalus) is a progressive disease

T M D'Hooghe, Thomas D’Hooghe, D'Hooghe TM, Bambra CS, Charanjit S. Bambra, C S Bambra, Raeymaekers BM, B M Raeymaekers, Barbara M. Raeymaekers, Koninckx PR, Philippe R. Koninckx, P R Koninckx
Fertility and sterility · 1996 · vol. 65(3) , pp. 645–649 · doi:10.1016/s0015-0282(16)58168-0 · PMID:8774301 · W2248424276
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Serial laparoscopies over 30 months revealed that endometriosis in captive baboons is a progressive disease.

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Abstract

OBJECTIVE: To test the hypothesis that spontaneous endometriosis is a progressive disease in baboons. DESIGN AND SETTING: Prospective cohort study, Institute of Primate Research, Nairobi, Kenya. PARTICIPANTS: Twelve baboons with histologically proven spontaneous endometriosis. INTERVENTIONS: Fifty-four serial laparoscopies (4.2 +/- 1.9 per animal, range 1 to 7) were performed after 1 to 3 months (n = 2), 4 to 6 months (n = 1), 7 to 9 months (n = 6), 10 to 12 months (n = 17), 13 to 15 months (n = 7), 16 to 18 months (n = 1), 19 to 21 months (n = 8), 22 to 24 months (n = 8), 25 to 27 months (n = 2), and 30 to 32 months (n = 2). MAIN OUTCOME MEASURE: During each laparoscopy the pelvis was examined for the presence of endometriosis. The number, size, and type of endometriotic implants were noted on a pelvic map and both endometriosis score and stage were calculated. Remodeling was defined as a change in laparoscopic appearance (typical, subtle, suspicious) of an individual endometriotic lesion. Data were analyzed by a signed rank test. RESULTS: Endometriosis was progressive as shown by the significant increase in the number and surface of lesions and in endometriosis scores after 24 months. The total number of endometriotic lesions after 24 months consisted of 69% new (and mostly subtle) implants, 10% remodeled lesions, and 21% unchanged implants. CONCLUSIONS: This study demonstrated that endometriosis in captive baboons undergoing repeated laparoscopies is a dynamic and moderately progressive disease with periods of development and regression and active remodeling between different types of lesions.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Laparoscopy Laparoscopy Monkey Diseases Papio Papio Animals Animals Cohort Studies Cohort Studies Disease Progression Disease Progression Endometriosis Endometriosis Endometriosis Female Female Longitudinal Studies Longitudinal Studies Monkey Diseases

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