Risk factors and biomarkers for the recurrence of ovarian endometrioma: about the immunoreactivity of progesterone receptor isoform B and nuclear factor kappa B

Ae Ra Han, Taek Hoo Lee, Sunzoo Kim, Hwa Young Lee
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2016 · vol. 33(1) , pp. 70–74 · doi:10.1080/09513590.2016.1205580 · PMID:27452080 · W2500001505
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This study identified dysmenorrhea severity, adenomyosis, higher PR-B, and lower NFκB immunoreactivity as risk factors and potential biomarkers for ovarian endometrioma recurrence.

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Abstract

Ovarian endometrioma is one of the important causes of poor ovarian reserve and up to half of them have been recurred. However, the treatment for recurrence prevention has limited efficiency and repeated surgery makes worsen the ovarian reserve. To find better management for recurrence prevention, we investigated risk factors and biomarkers for the recurrent endometriomas. The medical records of women with history of surgical dissection for ovarian endometrioma were collected. After exclusion of the cases with concurrent hysterectomy, been menopaused during follow-up, incomplete medical record, and loss of follow-up, a total of 134 women were enrolled. Immunohistochemical staining for progesterone receptor isoform B (PR-B) and nuclear factor kappa B (NFκB) was done with the fixed tissue blocks of their endometriomas which were collected at the time of surgery. Severity of dysmenorrhea and co-existence of adenomyosis had significant correlation with recurrence of endometrioma. Serum CA-125 level at the time of recurrence was higher than the highest level of CA-125 during follow-up in non-recurred group (55.6 versus 21.3 U/mL, p = 0.014). Increased PR-B (p = 0.041) and decreased NFκB (p = 0.036) immunoreactivity were found in recurrent group. However, to determine the possibility of immunoreactivity of PR-B and NFκB as biomarkers for recurrent endometrioma, further studies of various races and large numbers with prospective design are needed.

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Condition tags

mesh:D004715adenomyosisendometriomadysmenorrhea

MeSH descriptors

Endometriosis NF-kappa B Ovarian Diseases Receptors, Progesterone Adult Biomarkers Biomarkers Endometriosis Female Humans NF-kappa B Ovarian Diseases Protein Isoforms Receptors, Progesterone Recurrence Risk Factors Young Adult

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