Interleukin‐1: A possible role in the infertility associated with endometriosis
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This study found that interleukin-1 is present in the peritoneal fluid of women with endometriosis and toxic to mouse embryo development, suggesting it may contribute to endometriosis-associated infertility.
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Abstract
Increased numbers of activated macrophages are associated with mild endometriosis. Interleukin-1 (IL-1) is a protein produced by macrophages and is believed to be a primary mediator of host responses. IL-1 induces prostaglandin and fibrinogen synthesis and stimulates fibroblast proliferation. This study was undertaken to evaluate the role of IL-1 in the infertility associated with mild endometriosis. Peritoneal fluid (PF) was obtained at laparoscopy from 11 patients with minimal or mild endometriosis and from 7 women undergoing tubal ligation. Peritoneal macrophages were isolated and cultured for 24 hours. Peritoneal and macrophage culture fluids were studied for IL-1 activity, which was measured with the EL-4 assay. IL-1 activity was present in the PF of 10 of the 11 patients with endometriosis and 11 of the 11 macrophage culture fluids and was absent in the PF and macrophage culture fluid of the tubal ligation patients. The effect of recombinant alpha-IL-1 on the in vitro growth of 2-cell mouse embryos was also studied. IL-1 in concentrations similar to those present in the PF (greater than 1 U/ml) was toxic to mouse embryo development. We conclude that the IL-1 may play a role in the infertility associated with endometriosis.
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Cited by (50)
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- Dienogest May Reduce Estradiol- and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture- and Mouse Model-Based Study 2022
- Evaluating the effect of conditioned medium from endometrial stem cells on endometriosis-derived endometrial stem cells 2022
- Conditioned medium from healthy women's endometrial stem cells improve inflammatory and stemness- expression genes in endometriosis women 2021
- Alterations in the invasive properties of peripheral blood monocytes from patients with endometriosis 2019
- Interleukin-1β inhibits estrogen receptor-α, progesterone receptors A and B and biomarkers of human endometrial stromal cell differentiation: implications for endometriosis 2019
- Role of interleukin-32 in the pathogenesis of endometriosis: in vitro, human and transgenic mouse data 2018
- p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival 2017
- Decreased Progesterone Receptor B/A Ratio in Endometrial Cells by Tumor Necrosis Factor-Alpha and Peritoneal Fluid from Patients with Endometriosis 2016
- A New Therapy for Human Endometriosis: The Therapeutic Value of Leukotriene Receptor Antagonist for Endometriosis 2015
- Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence 2015
- Inflammation and nerve fiber interaction in endometriotic pain 2014
- mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium 2014
- Regulation of P21-Activated Kinase-4 by Progesterone and Tumor Necrosis Factor-α in Human Endometrium and Its Increased Expression in Advanced-Stage Endometriosis 2013
- Increased Nuclear Expression of Nuclear Factor Kappa‐B p65 Subunit in the Eutopic Endometrium and Ovarian Endometrioma of Women with Advanced Stage Endometriosis 2013
- Calcium‐binding protein expression in peritoneal endometriosis‐associated nerve fibres 2013
- Cytokines and Endometriosis - the Role of Immunological Alterations 2013
- Relationship Between Toll‐like Receptor‐4 and <scp>mPGES</scp>‐1 Gene Expression in Local Lesions of Endometriosis Patients 2012
- Analysis of cytokines in the peritoneal fluid of endometriosis patients as a function of the menstrual cycle stage using the Bio-Plex® platform 2012
- Endometriosis and Angiogenic Factors 2012
- Endocrine and inflammatory factors and endometriosis-associated infertility in assisted reproduction techniques 2012
- Neuroimmunomodulatory Alterations in Non-Lesional Peritoneum Close to Peritoneal Endometriosis 2012
- The emerging role of epigenetics in the aetiology of endometriosis. 2011
- The emerging role of epigenetics and miRNAs in endometriosis 2011
- Immune interactions in endometriosis 2011
- Decreased concentrations of soluble interleukin-1 receptor accessory protein levels in the peritoneal fluid of women with endometriosis 2011
- Up-regulation of p21-activated kinase 1 by in vitro treatment with interleukin 1-beta and its increased expression in ovarian endometriotic cysts 2011
- Distinct expression of the soluble and the membrane-bound forms of interleukin-1 receptor accessory protein in the endometrium of women with endometriosis 2011
- Imbalance between sympathetic and sensory innervation in peritoneal endometriosis 2011
- Endometriosis: Disease Classification and Behavior 2011
- Laparoscopic surgery for endometriosis-associated infertility: a pathophysiologic approach 2010
- Effect of peritoneal fluid from endometriosis patients on neuroblastoma cells in culture 2009
- Chapter 10 Endometriosis and Autoimmunity 2008
- Pyruvate reduces in vitro the embryotoxic effect of peritoneal fluid from infertile women with endometriosis 2008
- Involvement of nuclear factor-κB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin-1β in ectopic endometrial cells 2008
- Peritoneal macrophage depletion by liposomal bisphosphonate attenuates endometriosis in the rat model 2008
- Biomarkers of endometriosis 2008
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- Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility 2007
- Role of interleukin-1 receptor type II in the pathogenesis of endometriosis 2007
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- Imbalance in the expression of the activating type I and the inhibitory type II interleukin 1 receptors in endometriosis 2007
- Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions 2007
- Avaliação das concentrações das interleucinas 1-beta e 6 e da proteína amilóide A, no líquido peritoneal e no soro de pacientes com endometriose pélvica 2007
- Cytokines Regulate Matrix Metalloproteinases in Human Uterine Endometrial Fibroblast Cells Through a Mechanism That Does Not Involve Increases in Extracellular Matrix Metalloproteinase Inducer 2006
- Macrophage migration inhibitory factor expression in the intrauterine endometrium of women with endometriosis varies with disease stage, infertility status, and pelvic pain 2006
- Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? 2006
- Effect of endometrioma cystectomy on IVF outcome: a prospective randomized study 2006
- Effects of peritoneal fluid on preimplantation mouse embryo development and apoptosis in vitro 2005
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