Resveratrol reduces the expression of insulin-like growth factor-1 and hepatocyte growth factor in stromal cells of women with endometriosis compared with nonendometriotic women

Arablou T, Tahereh Arablou, Ali-Akbar Delbandi, Delbandi AA, Ali‐Akbar Delbandi, Sepideh Khodaverdi, Arefi S, Soheila Arefi, Roya Kolahdouz-Mohammadi, Roya Kolahdouz‐Mohammadi, Sahel Heidari, Mohammadi T, Tahereh Mohammadi, Naheed Aryaeian
Phytotherapy research : PTR · 2019 · vol. 33(4) , pp. 1044–1054 · doi:10.1002/ptr.6298 · PMID:30838714 · W2922147969
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Resveratrol treatment significantly decreased the gene and protein expression of IGF-1 and HGF in stromal cells from women with and without endometriosis, with a more pronounced effect on IGF-1 and HGF in ectopic stromal cells.

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Abstract

Resveratrol, a phytoalexin polyphenol, has antiproliferative, antiangiogenic, anti-inflammatory, and antioxidant properties. The present study has assessed the effect of resveratrol treatment on the expression of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) in endometrial stromal cells (ESCs) from women with and without endometriosis. Endometrial tissues were obtained from 40 endometriotic patients and 15 nonendometriotic control women. After the enzymatic digestion, 13 eutopic ESCs (EuESCs), 8 ectopic ESCs (EESCs), and 11 control ESCs (CESCs) were treated with resveratrol (100 μM) for 6, 24, and 48 hr. The gene and protein expressions of IGF-1 and HGF were measured using real-time polymerase chain reaction and enzyme-linked immunosorbent assay methods, respectively. Results showed that resveratrol treatment decreased significantly the gene expression of IGF-1 and HGF in EuESCs, EESCs, and CESCs (p < 0.05). The effect of resveratrol treatment on the reduction of IGF-1 gene expression was statistically more noticeable in EESCs compared with CESCs (p < 0.05). Also, in the case of HGF gene expression, the reducing effect of resveratrol treatment was statistically more considerable in EESCs compared with EuESCs and CESCs (p < 0.05 and p < 0.01, respectively). The IGF-1 and HGF protein production decreased significantly in EuESCs and EESCs (p < 0.05) but not in CESCs. These findings suggest that resveratrol treatment could reduce the expression of IGF-1 and HGF in ESCs especially in EESCs, which play a pivotal role in disease progression.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Endometrium Hepatocyte Growth Factor Insulin-Like Growth Factor I Peritoneal Diseases Resveratrol Adult Adult Case-Control Studies Case-Control Studies Cells, Cultured Cells, Cultured Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium

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