Global gene analysis of late secretory phase, eutopic endometrium does not provide the basis for a minimally invasive test of endometriosis

Sherwin JR, J. R. A. Sherwin, Andrew Sharkey, A M Sharkey, Attila Mihalyi, Mihalyi A, A Mihalyi, Péter Simsa, P Simsa, Simsa P, R D Catalano, Rob D. Catalano, Catalano RD, T M D'Hooghe, D'Hooghe TM, Thomas D’Hooghe
Human Reproduction · 2008 · vol. 23(5) , pp. 1063–1068 · doi:10.1093/humrep/den078 · PMID:18353903 · W2091963543
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Global gene analysis of late secretory phase endometrium revealed few differentially expressed transcripts between controls and endometriosis patients, precluding a minimally invasive diagnostic test.

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Abstract

BACKGROUND: Endometriosis occurs in 10% of women and is currently diagnosed by invasive laparoscopic testing. We tested the hypothesis that endometrial gene expression in late secretory phase endometrium differs between patients with and without endometriosis. METHODS: Ten patients with laparoscopically proven endometriosis (minimal/mild n = 5 and moderate/severe n = 5) and six controls, underwent endometrial biopsy in the late secretory phase (Day 23 onwards). Microarray interrogation of eutopic endometrial gene expression was performed. RESULTS: Microarray data were obtained for all control samples and eight samples from the endometriosis patients (n = 4 minimal/mild, n = 4 moderate/severe disease). Eight genes were identified as up-regulated and one gene was down-regulated in all endometriotic samples (more than 1.75-fold, P < 0.01). Real-time PCR analysis of protocadherin-17 (PCDH17), protein tyrosine phosphatase, receptor type, R (PTPRR) and interleukin-6 signal transducer (IL6ST) expression validated the microarray findings. CONCLUSIONS: Expression of very few transcripts differs, in late secretory eutopic endometrium, between controls and patients with endometriosis. The median fold changes of these genes are small. No transcripts were identified that could discriminate between minimal/mild and moderate/severe endometriosis. Therefore, interrogation of the late secretory endometrial transcriptome is not likely to form the basis of a minimally invasive diagnostic test for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Profiling Gene Expression Profiling Luteal Phase Cadherins Cadherins Cadherins Cytokine Receptor gp130 Cytokine Receptor gp130 Cytokine Receptor gp130 Down-Regulation Down-Regulation Endometriosis Endometriosis Endometrium Endometrium Female Female Humans

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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