Functional aspects of peritoneal macrophages in endometriosis of women
Observational
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⤵ 82 in-corpus citations
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Peritoneal macrophages in women with endometriosis exhibit increased erythrophagocytosis and reduced chemiluminescence, suggesting advanced differentiation that may impair gamete and embryo function.
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Abstract
Peritoneal fluid was collected in the periovulatory phase of the cycle from 25 women undergoing laparoscopy. Endometriosis was diagnosed in 13 patients (AFS score 1, N = 9; AFS score 2, N = 4) and 12 patients without endometriosis served as controls. In endometriosis patients the total peritoneal fluid cell number and cell concentration was significantly higher than in controls, indicating peritoneal irritation by endometrial implants. Peritoneal fluid macrophages in patients with endometriosis showed significantly increased erythrophagocytosis and lower chemiluminescence than in controls, suggesting an advanced differentiation of the macrophages in endometriosis patients. The macrophages in this stage of differentiation may interfere with gametes and embryos and thus contribute to endometriosis-associated subfertility.
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- Decreased Innate Migration of Pro-Inflammatory M1 Macrophages through the Mesothelial Membrane Is Affected by Ceramide Kinase and Ceramide 1-P 2022
- Estrogen-regulated CD200 inhibits macrophage phagocytosis in endometriosis 2020
- Alterations in the invasive properties of peripheral blood monocytes from patients with endometriosis 2019
- Pain Mechanisms in Peritoneal Diseases Might Be Partially Regulated by Estrogen 2017
- Macrophages promote the growth and invasion of endometrial stromal cells by downregulating IL-24 in endometriosis 2016
- Apoptosis induction of human endometriotic epithelial and stromal cells by noscapine 2016
- Niclosamide As a Potential Nonsteroidal Therapy for Endometriosis That Preserves Reproductive Function in an Experimental Mouse Model 2016
- Effect of Endometriosis on IVF Outcomes in Cases of Single Embryo Transfer for first IVF Attempt in Patients under 35 2016
- MAP kinases and the inflammatory signaling cascade as targets for the treatment of endometriosis? 2015
- Panels of cytokines and other secretory proteins as potential biomarkers of ovarian endometriosis 2015
- Asymmetric dimethylarginine (ADMA), nitric oxide metabolite, and estradiol levels in serum and peritoneal fluid in women with endometriosis 2015
- Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions 2014
- The effect of macrophages on fibroblast activity and lesion development in mouse models of endometriosis. 2014
- Roles of Prostaglandin E2 in Endometriosis 2014
- Endometriotic Epithelial Cell Response to Macrophage-Secreted Factors is Dependent on Extracellular Matrix Context 2014
- Macrophages in Pathophysiology of Endometriosis 2014
- C-reactive protein of serum and peritoneal fluid in endometriosis 2012
- Regulación del crecimiento del tejido endometrial en respuesta a nuevas alternativas terapéuticas propuestas para tratar la endometriosis 2012
- Influence of nerve growth factor in endometriosis-associated symptoms 2011
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- Pathophysiological factors and genetic association in endometriosis 2011
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- Prostaglandin E2: the master of endometriosis? 2010
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- Reproductive Surgery for Endometriosis-Associated Infertility 2008
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- Transforming growth factor beta1 gene polymorphism 509C/T in deep infiltrating endometriosis 2007
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- Suppression of matrix metalloproteinase-9 by prostaglandin E(2) in peritoneal macrophage is associated with severity of endometriosis 2005
- Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies 2005
- Human leukocyte antigen expression by peritoneal macrophages from women with pelvic endometriosis is depressed but coordinated with costimulatory molecule expression 2005
- The presence of endometrial cells in the peritoneal cavity enhances monocyte recruitment and induces inflammatory cytokines in mice: implications for endometriosis 2004
- Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease? 2003
- Coordinated but depressed expression of human leukocyte antigen-DR, intercellular adhesion molecule-1, and CD14 on peritoneal macrophages in women with pelvic endometriosis 2003
- Pathogenesis of endometriosis 2003
- Diagnosis and treatment of endometriosis 2003
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- Immunology and endometriosis 2003
- Nitric oxide synthesis is increased in the endometrial tissue of women with endometriosis 2003
- Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis 2002
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- pubmed
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