Concentration of TNF-α in the peritoneal fluid and serum of endometriotic patients

TEDJA DANUDJA OEPOMO, Tedjo Danudjo Oepomo
In: Biodiversitas Journal of Biological Diversity · 2006 · vol. 7(3) · doi:10.13057/biodiv/d070302 · W2318023289
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This study found significantly higher TNF-α concentrations in the peritoneal fluid and serum of endometriosis patients compared to controls, with serum TNF-α reflecting peritoneal fluid levels.

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This study measured tumor necrosis factor alpha (TNF-α) concentrations in peritoneal fluid and serum from 20 women undergoing laparoscopic surgery for endometriosis (endometriosis group) and compared them with 20 women undergoing interval laparoscopic sterilization as controls. TNF-α was quantified in both fluids using ELISA during laparoscopy. TNF-α levels differed significantly between the endometriosis and control groups, and TNF-α concentrations in peritoneal fluid and serum showed a strong positive correlation in the endometriosis group. A stated limitation is that the paper does not report broader methodological details (e.g., effect size or adjustment for confounders) beyond the basic statistical tests used, focusing instead on statistical associations and a derived threshold from sensitivity/specificity. This paper is centrally about endometriosis — it examines TNF-α concentration in peritoneal fluid and serum in endometriotic patients.

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Abstract

The aim of this research was to expose the relation between tumor necrosis factor alpha (TNF-α) in the peritoneal fluid and in the serum of endometriosis patients. It was conducted at Dr. Muwardi Hospital Surakarta. Twenty patients undergoing laparoscopic operation because of endometriosis indication (Endometriosis Group), 20 women (aged 23 to 40) who undergo interval sterilization by means of laparoscopic technique. During laparoscopic operation, peritoneal fluid is taken to examine TNF-α by ELISA technique. At the same time, the serum isalso taken to examine TNF-α by the same technique. The research result indicated that by independent sample t-test, the TNF-α concentration in the Endometriosis Group is quite different from the control group (P=0.00). The simple linear regression test shows a strong positive one-way correlative relation between TNF-α concentration in the peritoneal fluid and TNF-α concentration in the serum in the Endometriosis Group. The research result indicated that the TNF-α concentration in the serum can be used as a reflection of endometriosis. A statistical test is done to find the limit value based on sensitivity and specification.© 2006 Jurusan Biologi FMIPA UNS SurakartaKey words: endometriosis, TNF-α, peritoneal fluid, serum.
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Concentration of TNF-α in the peritoneal fluid and serum of endometriotic patients Main Article Content Abstract The aim of this research was to expose the relation between tumor necrosis factor alpha (TNF-α) in the peritoneal fluid and in the serum of endometriosis patients. It was conducted at Dr. Muwardi Hospital Surakarta. Twenty patients undergoing laparoscopic operation because of endometriosis indication (Endometriosis Group), 20 women (aged 23 to 40) who undergo interval sterilization by means of laparoscopic technique. During laparoscopic operation, peritoneal fluid is taken to examine TNF-α by ELISA technique. At the same time, the serum is also taken to examine TNF-α by the same technique. The research result indicated that by independent sample t-test, the TNF-α concentration in the Endometriosis Group is quite different from the control group (P=0.00). The simple linear regression test shows a strong positive one-way correlative relation between TNF-α concentration in the peritoneal fluid and TNF-α concentration in the serum in the Endometriosis Group. The research result indicated that the TNF-α concentration in the serum can be used as a reflection of endometriosis. A statistical test is done to find the limit value based on sensitivity and specification. © 2006 Jurusan Biologi FMIPA UNS Surakarta Key words: endometriosis, TNF-α, peritoneal fluid, serum.

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endometriosis

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