Cellular and genetic constitution of human endometriosis tissues

J Gogusev, Jean Gogusev, Gogusev J, Jean Bouquet de Jolinière, Bouquet de Jolinière J, J Bouquet de Jolinière, L Telvi, Telvi L, Louise Telvi, M Doussau, Doussau M, Mireille Doussau, Alexandre Stojkoski, A Stojkoski, Stojkoski A, M Levardon, Levardon M, Michel Levradon
Journal of the Society for Gynecologic Investigation · 2000 · vol. 7(2) , pp. 79–87 · doi:10.1177/107155760000700201 · PMID:10785606 · W2024066900
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This paper characterized the cellular and genetic makeup of human endometriosis tissues.

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Abstract

For many years, endometriosis has been an enigmatic and confusing disorder, but there have been recent contributions to the subject, provided by modern techniques in cellular and molecular biology, regarding the cell lineage involved, the stage of differentiation, and genomic features. This review deals mainly with the cellular, cytochemical, cytogenetic, and molecular cytogenetic features of primary endometriotic lesions and cultured endometriotic cells. The FbEM-1 cell line, taken as an in vitro model, showed cell proliferation and differentiation features suggesting an immature endometriosis-related cell lineage. Chromosomal analysis of these cells demonstrate a complex karyotype including a rearrangement interpreted as der(5) t(5q34;6p11) indicating a clonal cell proliferation. Data of recurrent DNA sequence copy number alterations detected by the comparative genomic hybridization in a series of primary endometriotic lesions also are described. Predominant recurrent anomalies were found on chromosome 1p and 22q in 50% of the studied samples. Additional losses were seen on chromosomes 5p(33%), 6q(27%), 7p(22%), 9q(22%), and 1q(22%), as well as on 17q segments in one case. Gain of DNA sequences was seen on chromosomes 6q, 7q, and 17q. The potential role of the genetic changes identified are discussed in relation to the putative oncogenes and/or tumor suppressor genes possibly involved in development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Animals Animals Cell Differentiation Cell Differentiation Cell Division Cell Division Cell Line Cell Line Endometriosis Endometriosis Endometriosis Female Female Humans Humans Loss of Heterozygosity Loss of Heterozygosity Phenotype Phenotype

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (12)

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